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The Short Chain Amide and Urea Porin (SAP) Family [Function: Specific channels] Seed alignment | Full alignment in OMPdb

The prototype of this family, FmdC, is a porin involved in the transport of short-chain amides and urea through the outer membrane of Methylophilus methylotrophus under conditions where these nitrogen sources are present at a very low concentration. Its synthesis is inducible by short-chain amides and urea and the protein is believed to transport these molecules across the outer membrane. Homologs are found in a variety of Gram-negative bacteria, like Geobacter sulfurreducens, Geobacter metallireducens, Methylobacillus flagellatus and Aquifex aeolicus. The AQ_1862 from Aquifex aeolicus has been shown to be outer membrane-localized and to possess channel properties.


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Literature references

An outer-membrane porin inducible by short-chain amides and urea in the methylotrophic bacterium Methylophilus methylotrophus
Microbiology (Reading). 1997 Jul;143 ( Pt 7):2373-9. doi: 10.1099/00221287-143-7-2373.
PMID: 9245819

Protein AQ_1862 from the hyperthermophilic bacterium Aquifex aeolicus is a porin and contains two conductance pathways of different selectivity
Biophys J. 2007 Oct 15;93(8):2667-77. doi: 10.1529/biophysj.107.108803. Epub 2007 Jun 22.
PMID: 17586565


Elixir UTH dib compgen