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The General Bacterial Porin (GBP-1) Family 1 [Function: Non-specific channels] Seed alignment | Full alignment in OMPdb | |
This family consists of the general diffusion porins from mainly the Beta and Gamma subdivisions of Proteobacteria. Although the porins of this family share common structural and functional properties with the porins of General Bacterial Porin Family 2 (GBP-2) and the Rhodobacter porin family, their sequence similarity is rather low. The porins form large aqueous channels, facilitating the diffusion of small hydrophilic molecules through the outer membrane in a non-specific manner. Important aspects of the channel activity are the conductance, the voltage dependence and the pH sensitivity. Several porins of this family have been determined at low resolution (Omp32, OmpF, Phosphoporin, OmpK36) suggesting that the 16-stranded ß-barrel is a common structural feature. In addition to that, the porins of this family seem to require trimerization in order to function properly. | |
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Literature references | |
The bacterial porin superfamily: sequence alignment and structure prediction Mol Microbiol. 1991 Sep;5(9):2153-64. doi: 10.1111/j.1365-2958.1991.tb02145.x. PMID: 1662760 | |
Solute uptake through general porins Front Biosci. 2003 May 1;8:d1055-71. doi: 10.2741/1132. PMID: 12700124 | |
The structure of OmpF porin in a tetragonal crystal form Structure. 1995 Oct 15;3(10):1041-50. doi: 10.1016/s0969-2126(01)00240-4. PMID: 8589999 | |
Crystal structures explain functional properties of two E. coli porins Nature. 1992 Aug 27;358(6389):727-33. doi: 10.1038/358727a0. PMID: 1380671 | |
Crystal structures of the OmpF porin: function in a colicin translocon EMBO J. 2008 Aug 6;27(15):2171-80. doi: 10.1038/emboj.2008.137. Epub 2008 Jul 17. PMID: 18636093 | |
Cation-selective pathway of OmpF porin revealed by anomalous X-ray diffraction J Mol Biol. 2010 Feb 19;396(2):293-300. doi: 10.1016/j.jmb.2009.11.042. Epub 2009 Nov 20. PMID: 19932117 | |
Crystal structure of osmoporin OmpC from E. coli at 2.0 A J Mol Biol. 2006 Oct 6;362(5):933-42. doi: 10.1016/j.jmb.2006.08.002. Epub 2006 Aug 3. PMID: 16949612 | |
Crystal structure of Omp32, the anion-selective porin from Comamonas acidovorans, in complex with a periplasmic peptide at 2.1 A resolution Structure. 2000 Sep 15;8(9):981-92. doi: 10.1016/s0969-2126(00)00189-1. PMID: 10986465 | |
High resolution crystal structures and molecular dynamics studies reveal substrate binding in the porin Omp32 J Biol Chem. 2006 Mar 17;281(11):7413-20. doi: 10.1074/jbc.M510939200. Epub 2006 Jan 23. PMID: 16434398 | |
Crystal structure and functional characterization of OmpK36, the osmoporin of Klebsiella pneumoniae Structure. 1999 Apr 15;7(4):425-34. doi: 10.1016/s0969-2126(99)80055-0. PMID: 10196126 | |
Structural basis for solute transport, nucleotide regulation, and immunological recognition of Neisseria meningitidis PorB Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6811-6. doi: 10.1073/pnas.0912115107. Epub 2010 Mar 29. PMID: 20351243 | |
Proteins in this family with 3D-structure | |
S5UCA2 | |
F2VN85 | |
A0A0H3FYJ7 | |
W1E8X3 | |
E3U904 | |
Q9ALY0 | |
A0A0M7H8A9 | |
Q51056 | |
P30690 | |
P02931 | |
P0A264 | |
Q8CVW1 | |
Q9K597 | |
P06996 | |
P02932 | |
P37432 | |
Q48473 | |
Q5RT80 | |
E3U905 | |
Q93K99 | |
D6QLY0 | |
E5G6G2 | |
D6QLY1 |
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