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This family contains outer membrane proteins responsible for carbapenem resistance in the Moraxellaceae family of Gamma-Proteobacteria. Resistance to both imipenem and meropenem in multidrug-resistant clinical strains of Acinetobacter baumannii is associated with the loss of a heat-modifiable 29 kDa outer membrane protein, designated carO, which was the first identified member of the family and its structure revealed an 8-stranded monomeric ß-barrel.
Acquisition of resistance to carbapenems in multidrug-resistant clinical strains of Acinetobacter baumannii: natural insertional inactivation of a gene encoding a member of a novel family of beta-barrel outer membrane proteins
Antimicrob Agents Chemother. 2005 Apr;49(4):1432-40. doi: 10.1128/AAC.49.4.1432-1440.2005.
Channel formation by CarO, the carbapenem resistance-associated outer membrane protein of Acinetobacter baumannii
Antimicrob Agents Chemother. 2005 Dec;49(12):4876-83. doi: 10.1128/AAC.49.12.4876-4883.2005.
|Proteins in this family with 3D-structure|