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The Fusobacterial Outer Membrane Porin (fomA) Family [Function: Non-specific diffusion channels] Seed alignment | Full alignment

This is a small family named after the porin fomA found n the outer membrane of Fusobacterium nucleatum. FomA is a trimeric protein, which exhibits channel properties similar to that of the other general porins. Deletions in the largest proposed external region (loop L6), made the fomA porins considerably more permeable to antibiotics, indicating larger pore channels. Results obtained from limited proteolysis of purified fomA, indicate that the N-terminal part of the protein is not an integral part of the ß-barrel, but forms a periplasmic domain instead, therefore the protein is proposed to form the ß-barrel distinct from the periplasmic N-terminal domain.

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Literature references

ROS-mediated lipid peroxidation as a result of Cu(ii) interaction with FomA protein fragments of F. nucleatum: relevance to colorectal carcinogenesis
Metallomics. 2019 Dec 11;11(12):2066-2077. doi: 10.1039/c9mt00179d.
PMID: 31657425

Cu(II) Complexes with FomA Protein Fragments of Fusobacterium Nucleatum Increase Oxidative Stress and Malondialdehyde Level
Chem Res Toxicol. 2019 Nov 18;32(11):2227-2237. doi: 10.1021/acs.chemrestox.9b00269. Epub 2019 Oct 11.
PMID: 31569943

Stability of Cu(ii) complexes with FomA protein fragments containing two His residues in the peptide chain
Metallomics. 2019 Sep 1;11(9):1518-1531. doi: 10.1039/c9mt00131j. Epub 2019 Aug 28.
PMID: 31460537

[Acquisition and the immunogenicity of the outer membrane FomA protein of Fusobacterium nucleatum]
Zhonghua Kou Qiang Yi Xue Za Zhi. 2018 Oct 9;53(10):674-680. doi: 10.3760/cma.j.issn.1002-0098.2018.10.006.
PMID: 30392224

Biochemical characterization of a recombinant Lactobacillus acidophilus strain expressing exogenous FomA protein
Arch Oral Biol. 2018 Aug;92:25-31. doi: 10.1016/j.archoralbio.2018.04.016. Epub 2018 Apr 30.
PMID: 29747062

Relationship between copper(ii) complexes with FomA adhesin fragments of F. nucleatum and colorectal cancer. Coordination pattern and ability to promote ROS production
Dalton Trans. 2018 Apr 17;47(15):5445-5458. doi: 10.1039/c7dt04103a.
PMID: 29595860

[A preliminary study on the effect of histatin 5 inhibiting Porphyromonas gingivalis and Fusobacterium nucleatum co-aggregation]
Zhonghua Kou Qiang Yi Xue Za Zhi. 2018 Mar 9;53(3):150-156. doi: 10.3760/cma.j.issn.1002-0098.2018.03.002.
PMID: 29972970

One-step purification and porin transport activity of the major outer membrane proteins P2 from Haemophilus influenzae, FomA from Fusobacterium nucleatum and PorB from Neisseria meningitidis
Appl Biochem Biotechnol. 2015 Mar;175(6):2907-15. doi: 10.1007/s12010-014-1473-2. Epub 2015 Jan 10.
PMID: 25575589

Identification of an outer membrane protein of Fusobacterium necrophorum subsp. necrophorum that binds with high affinity to bovine endothelial cells
Vet Microbiol. 2015 Mar 23;176(1-2):196-201. doi: 10.1016/j.vetmic.2014.12.015. Epub 2014 Dec 24.
PMID: 25601800

The protective effect of recombinant FomA-expressing Lactobacillus acidophilus against periodontal infection
Inflammation. 2013 Oct;36(5):1160-70. doi: 10.1007/s10753-013-9651-x.
PMID: 23644821

Halitosis vaccines targeting FomA, a biofilm-bridging protein of fusobacteria nucleatum
Curr Mol Med. 2013 Sep;13(8):1358-67. doi: 10.2174/15665240113139990063.
PMID: 23865430

The lipid bilayer-inserted membrane protein BamA of Escherichia coli facilitates insertion and folding of outer membrane protein A from its complex with Skp
Biochemistry. 2013 Jun 11;52(23):3974-86. doi: 10.1021/bi400103t. Epub 2013 May 24.
PMID: 23641708

Structural characterization of the fusobacterial non-specific porin FomA suggests a 14-stranded topology, unlike the classical porins
Microbiology (Reading). 2002 Nov;148(Pt 11):3395-3403. doi: 10.1099/00221287-148-11-3395.
PMID: 12427931

Topological investigations of the FomA porin from Fusobacterium nucleatum and identification of the constriction loop L6
Microbiology (Reading). 2001 Apr;147(Pt 4):1059-1067. doi: 10.1099/00221287-147-4-1059.
PMID: 11283301

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