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The Outer Membrane Protein X (OmpX) Family [Function: Adhesion] Seed alignment | Full alignment in OMPdb

This family consists of several bacterial and phage virulence-related outer membrane proteins which are essential for the bacterial survival within macrophages and for eukaryotic cell invasion. These proteins consist of 8 transmembrane beta sheets and 4 cell surface-exposed mobile loops, as suggested by the structure of OmpX of Escherichia coli. The Ail protein of Yersinia enterocolitica is also a known virulence factor. It is thought that it directly promotes invasion and loop 2 contains an active site, perhaps a receptor-binding domain. The phage protein Lom is expressed during lysogeny and encodes host-cell envelope proteins. PagC of Salmonella typhimurium is required for survival in macrophages and for virulence in mice.


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Literature references

PhoP/PhoQ: macrophage-specific modulators of Salmonella virulence?
Mol Microbiol. 1991 Sep;5(9):2073-8. doi: 10.1111/j.1365-2958.1991.tb02135.x.
PMID: 1766380

Nucleotide sequence of the Yersinia enterocolitica ail gene and characterization of the Ail protein product
J Bacteriol. 1990 Feb;172(2):1062-9. doi: 10.1128/jb.172.2.1062-1069.1990.
PMID: 1688838

Role of YadA, Ail, and Lipopolysaccharide in Serum Resistance of Yersinia enterocolitica Serotype O:3
Infect Immun. 2005 Apr;73(4):2232-44. doi: 10.1128/IAI.73.4.2232-2244.2005.
PMID: 15784567

A Salmonella typhimurium virulence protein is similar to a Yersinia enterocolitica invasion protein and a bacteriophage lambda outer membrane protein
J Bacteriol. 1991 Jan;173(1):86-93. doi: 10.1128/jb.173.1.86-93.1991.
PMID: 1846140

Structural insights into Ail-mediated adhesion in Yersinia pestis
Structure. 2011 Nov 9;19(11):1672-82. doi: 10.1016/j.str.2011.08.010.
PMID: 22078566

The structure of the outer membrane protein OmpX from Escherichia coli reveals possible mechanisms of virulence
Structure. 1999 Oct 15;7(10):1301-9. doi: 10.1016/s0969-2126(00)80063-5.
PMID: 10545325

Transverse relaxation-optimized NMR spectroscopy with the outer membrane protein OmpX in dihexanoyl phosphatidylcholine micelles
Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2358-63. doi: 10.1073/pnas.051629298. Epub 2001 Feb 20.
PMID: 11226244

NMR structure of the integral membrane protein OmpX
J Mol Biol. 2004 Mar 5;336(5):1211-21. doi: 10.1016/j.jmb.2003.09.014.
PMID: 15037080

Proteins in this family with 3D-structure

P0A917


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