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The Putative general bacterial porin (Porin_7/Acinetobacter baumannii 34-kDa) Family [Function: Specific diffusion channels] Seed alignment | Full alignment | Pfam page

Members of this family are found mainly in Acinetobacter and some of them are implicated in the resistance against imipenem. This 34-kDa family is distantly related to the CarO family. In Acinetobacter baumannii, the X-ray crystal structure of Omp33 at a resolution of 2.1 Å reported that Omp33 forms a 14-ß-stranded barrel. without stable extracellular loop constrictions. Instead, an extended and unusual periplasmic turn connecting ß-strands 2 and 3 is present, which folds into the pore lumen and completely blocks the aqueous channel.


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Literature references


Specific egg yolk antibodies (IgY) confer protection against Acinetobacter baumannii in a murine pneumonia model
J Appl Microbiol. 2019 Feb;126(2):624-632. doi: 10.1111/jam.14135. Epub 2018 Nov 22.
PMID: 30353977

Crystal structure of the Acinetobacter baumannii outer membrane protein Omp33
Acta Crystallogr D Struct Biol. 2018 Sep 1;74(Pt 9):852-860. doi: 10.1107/S205979831800904X. Epub 2018 Sep 3.
PMID: 30198896

Acinetobacter spp. porin Omp33-36: Classification and transcriptional response to carbapenems and host cells
PLoS One. 2018 Aug 2;13(8):e0201608. doi: 10.1371/journal.pone.0201608. eCollection 2018.
PMID: 30071077

An integrative in silico approach to the structure of Omp33-36 in Acinetobacter baumannii
Comput Biol Chem. 2018 Feb;72:77-86. doi: 10.1016/j.compbiolchem.2018.01.003. Epub 2018 Jan 12.
PMID: 29414099

Highly conserved exposed immunogenic peptides of Omp34 against Acinetobacter baumannii: An innovative approach
J Microbiol Methods. 2018 Jan;144:79-85. doi: 10.1016/j.mimet.2017.11.008. Epub 2017 Nov 10.
PMID: 29133159

Virulence characteristics of Acinetobacter baumannii clinical isolates vary with the expression levels of omps
J Med Microbiol. 2017 Feb;66(2):203-212. doi: 10.1099/jmm.0.000394. Epub 2017 Mar 7.
PMID: 27902395

The Acinetobacter baumannii Omp33-36 porin is a virulence factor that induces apoptosis and modulates autophagy in human cells
Infect Immun. 2014 Nov;82(11):4666-80. doi: 10.1128/IAI.02034-14. Epub 2014 Aug 25.
PMID: 25156738

Association of the outer membrane protein Omp33 with fitness and virulence of Acinetobacter baumannii
J Infect Dis. 2013 Nov 15;208(10):1561-70. doi: 10.1093/infdis/jit386. Epub 2013 Aug 1.
PMID: 23908480

Global comparison of the membrane subproteomes between a multidrug-resistant Acinetobacter baumannii strain and a reference strain
J Proteome Res. 2006 Dec;5(12):3385-98. doi: 10.1021/pr060372s.
PMID: 17137340

Channel formation by CarO, the carbapenem resistance-associated outer membrane protein of Acinetobacter baumannii
Antimicrob Agents Chemother. 2005 Dec;49(12):4876-83. doi: 10.1128/AAC.49.12.4876-4883.2005.
PMID: 16304148

Loss of a 29-kilodalton outer membrane protein in Acinetobacter baumannii is associated with imipenem resistance
J Clin Microbiol. 2002 Dec;40(12):4776-8. doi: 10.1128/jcm.40.12.4776-4778.2002.
PMID: 12454194

Imipenem resistance among Acinetobacter baumannii: association with reduced expression of a 33-36 kDa outer membrane protein
J Antimicrob Chemother. 1996 Aug;38(2):245-51. doi: 10.1093/jac/38.2.245.
PMID: 8877538

Proteins in this family with 3D-structure
View Entry
Description
Organism
Length
# strands
Putative 34 kDa outer membrane protein
Acinetobacter baumannii 754286
293
14


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