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COG4313 proteins comprise a huge and widespread family of outer membrane channels and have been involved in the uptake of a set of hydrophobic molecules. The first studied member of COG4313 proteins was the TcpY, an outer membrane protein that eases the uptake of polychlorophenols across the outer membrane of Cupriavidus necator JMP134. Pput2725 is another member of the family and forms a 12-stranded barrel at the outer membrane of Pseudomonas putida with experimentally verifier 3D structure. It is suggested that Pput2725 mediates the uptake of hydrophobic aromatic compounds.
Crystal structure of a COG4313 outer membrane channel
Sci Rep. 2015 Jul 7;5:11927. doi: 10.1038/srep11927.
A beta-barrel outer membrane protein facilitates cellular uptake of polychlorophenols in Cupriavidus necator
Biodegradation. 2010 Jun;21(3):431-9. doi: 10.1007/s10532-009-9313-8. Epub 2009 Nov 24.
|Proteins in this family with 3D-structure|