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The NilB Family [Function: Unknown] Seed alignment | Full alignment in OMPdb | |
NilB is a surface-exposed outer membrane protein. Expression of NilB is suppressed by NilR and growth in nutrient-rich medium. Members of this family exist in diverse bacteria and are common in the genomes of mucosal pathogens. Bioinformatic analyses reported that NilB is the only characterized member of a family of proteins distinguished by a conserved C-terminal domain of unknown function (DUF560) and N-terminal region tetratricopeptide repeats (TPR). Insertion and deletion mutational analyses revealed that NilB forms a beta barrel with 14 transmembrane strands and seven extracellular surface loops, and an N-terminal globular domain. The globular domain and surface loop 6 have a crucial role in the nematode colonization. Epifluorescence microscopy of these mutants revealed that NilB is necessary at early stages of colonization. | |
Literature references | |
Mutational analyses reveal overall topology and functional regions of NilB, a bacterial outer membrane protein required for host association in a model of animal-microbe mutualism J Bacteriol. 2012 Apr;194(7):1763-76. doi: 10.1128/JB.06711-11. Epub 2012 Jan 27. PMID: 22287518 | |
Substrate specificity within a family of outer membrane carboxylate channels PLoS Biol. 2012 Jan;10(1):e1001242. doi: 10.1371/journal.pbio.1001242. Epub 2012 Jan 17. PMID: 22272184 |
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