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TraF is a 26 kDa periplasmic protein necessary for F pilus extension, and deletions at either termini abolish F pili formation eliminating conjugative gene transfer. The NTD of TraF exhibits increased structural dynamics and is responsible for interactions with TraH; the CTD (Glu127-Leu247) contains a thioredoxin-like fold. Through Phyre2 modeling the structure of TraF is predicted to have at least three -helices bordered by a four-strand -sheet.
Comparative Genomics of the Conjugation Region of F-like Plasmids: Five Shades of F
Front Mol Biosci. 2016 Nov 10;3:71. doi: 10.3389/fmolb.2016.00071. eCollection 2016.
F plasmid TraF and TraH are components of an outer membrane complex involved in conjugation
J Bacteriol. 2010 Mar;192(6):1730-4. doi: 10.1128/JB.00726-09. Epub 2010 Jan 15.
The product of the F plasmid transfer operon gene, traF, is a periplasmic protein
J Bacteriol. 1988 Aug;170(8):3633-9. doi: 10.1128/jb.170.8.3633-3639.1988.