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The Alginate Export Porin (algE) Family [Function: Biogenesis/Secretion] Seed alignment | Full alignment | Pfam page | TC-DB page | ||||
Proteins of the AEP family are believed to export alginate (an acidic polysaccharide), across the outer membrane of Gram-negative bacteria. These proteins span the outer membrane forming a large ß-barrel comprised of 18 ß sheets, as the 3D structure of one of the family's members suggests. AlgE is a monomeric 18-stranded ß-barrel protein required for secretion of the extracellular polysaccharide alginate in Pseudomonas aeruginosa. | ||||
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| Literature references | ||||
Alginate Biosynthesis Factories in Pseudomonas fluorescens: Localization and Correlation with Alginate Production Level Appl Environ Microbiol. 2015 Dec 11;82(4):1227-1236. doi: 10.1128/AEM.03114-15. Print 2016 Feb 15. PMID: 26655760 | ||||
A conformational landscape for alginate secretion across the outer membrane of Pseudomonas aeruginosa Acta Crystallogr D Biol Crystallogr. 2014 Aug;70(Pt 8):2054-68. doi: 10.1107/S1399004714001850. Epub 2014 Jul 25. PMID: 25084326 | ||||
Insights into the assembly of the alginate biosynthesis machinery in Pseudomonas aeruginosa Appl Environ Microbiol. 2013 May;79(10):3264-72. doi: 10.1128/AEM.00460-13. Epub 2013 Mar 15. PMID: 23503314 | ||||
Dual roles of Pseudomonas aeruginosa AlgE in secretion of the virulence factor alginate and formation of the secretion complex Appl Environ Microbiol. 2013 Mar;79(6):2002-11. doi: 10.1128/AEM.03960-12. Epub 2013 Jan 18. PMID: 23335756 | ||||
Structural basis for alginate secretion across the bacterial outer membrane Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13083-8. doi: 10.1073/pnas.1104984108. Epub 2011 Jul 21. PMID: 21778407 | ||||
The Azotobacter vinelandii gene algJ encodes an outer-membrane protein presumably involved in export of alginate Microbiology (Reading). 1996 Apr;142 ( Pt 4):873-80. doi: 10.1099/00221287-142-4-873. PMID: 8936313 | ||||
Overexpression of algE in Escherichia coli: subcellular localization, purification, and ion channel properties J Bacteriol. 1994 Sep;176(18):5639-47. doi: 10.1128/jb.176.18.5639-5647.1994. PMID: 7521870 | ||||
| Proteins in this family with 3D-structure | ||||
View Entry | Description | Organism | Length | # strands |
Mitochondrial distribution and morphology protein 10 |
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 490 |
18 |
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