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NfrA of Escherichia coli was found to be one of the two genes whose products are required for bacteriophage N4 adsorption. The nfrA gene encodes a 990-residue long outer membrane protein which presumably serves as the phage receptor, whereas the nfrB gene encodes an inner membrane protein and may be a component of the receptor. Besides acting as receptor for N4 bacteriophage, the physiological role of nrfA is unknown. The transmembrane domain of the protein is located in the C-terminus whereas a large N-terminal periplasmic domain of unknown function (TPR) domain, which is known to be associated with protein-protein interactions, is also present.
Proteomic analysis of the Escherichia coli outer membrane
Eur J Biochem. 2000 May;267(10):2871-81. doi: 10.1046/j.1432-1327.2000.01296.x.
Genetic analysis of bacteriophage N4 adsorption
J Bacteriol. 1989 Sep;171(9):4595-602. doi: 10.1128/jb.171.9.4595-4602.1989.
Two overlapping genes encoding membrane proteins required for bacteriophage N4 adsorption
J Bacteriol. 1993 Nov;175(21):7081-5. doi: 10.1128/jb.175.21.7081-7085.1993.