This family consists of several adhesins found mainly in enterohaemorrhagic and enteropathogenic Escherichia coli (EHEC and EPEC respectively), termed intimins, and invasins found in Yersinia pseudotuberculosis. Intimins and Invasins, share homology in their N-terminal (500 amino acids in length) segment that forms a 12-stranded ß-barrel, anchoring the protein to the outer membrane. At the C-terminal, these proteins have some Ig-like domains and a C-type lectin domain. Invasin binds to Integrin, whereas Intimin binds to the Translocated Intimin Receptor (Tir). Homologs are also found in other pathogenic bacteria, such as Citrobacter, Shigella, Salmonella, Bordetella and Campylobacter.

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