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The Leptospira Porin OmpL1 (LP-OmpL1) Family [Function: Non-specific channels] Seed alignment | Full alignment in OMPdb

This family consists of proteins found in spirochetes of the genus Leptospira. OmpL1, is a heat modifiable porin that can form trimeric structures. OmpL1 has been reconstituted in planar lipid bilayers where an average single channel conductance similar to those of the major porin activity of native leptospiral membranes, was demonstrated. OmpL1 is expressed during infection and, therefore, has a role in the induction and persistence of leptospiral interstitial nephritis.

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Literature references

The rare outer membrane protein, OmpL1, of pathogenic Leptospira species is a heat-modifiable porin
Infect Immun. 1995 Aug;63(8):3174-81. doi: 10.1128/IAI.63.8.3174-3181.1995.
PMID: 7622245

Leptospiral outer membrane proteins OmpL1 and LipL41 exhibit synergistic immunoprotection
Infect Immun. 1999 Dec;67(12):6572-82.
PMID: 10569777

Expression and distribution of leptospiral outer membrane components during renal infection of hamsters
Infect Immun. 1999 Feb;67(2):853-61. doi: 10.1128/IAI.67.2.853-861.1999.
PMID: 9916100

Leptospira: a spirochaete with a hybrid outer membrane
Mol Microbiol. 2010 Aug;77(4):805-14. doi: 10.1111/j.1365-2958.2010.07262.x. Epub 2010 Jun 28.
PMID: 20598085

Elixir UTH dib compgen