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The Chlamydia major outer membrane protein Family [Function: Non-specific diffusion channels] Seed alignment | Full alignment | Pfam page | TC-DB page | ||||
The Chlamydial Major Outer Membrane Protein (MOMP), functions to permit the diffusion of solutes through the intrareticular body membrane. MOMP is predicted to form a ß barrel, with 4 highly variable and immunogenic extracellular loops that determine the different serotypes. The four variable loops are not required for pore formation but rather serve in the modification of the channel function. 7 cysteines are found conserved in these loops, and disulfide bonds are formed between Cys(48)-Cys(55), Cys(201)-Cys(203), whereas Cys(51), Cys(136), Cys(226), and Cys(351), are free cysteines and, therefore, could potentially form disulfide-linked complexes with other MOMPs or other membrane components. | ||||
| Literature references | ||||
Super-Resolution Fluorescence Microscopy Reveals Clustering Behaviour of Chlamydia pneumoniae's Major Outer Membrane Protein Biology (Basel). 2020 Oct 20;9(10):344. doi: 10.3390/biology9100344. PMID: 33092039 | ||||
Vaccination with the recombinant major outer membrane protein elicits long-term protection in mice against vaginal shedding and infertility following a Chlamydia muridarum genital challenge NPJ Vaccines. 2020 Oct 1;5:90. doi: 10.1038/s41541-020-00239-7. eCollection 2020. PMID: 33083025 | ||||
Capturing Complex Vaccine-Immune-Disease Relationships for Free-Ranging Koalas: Higher Chlamydial Loads Are Associated With Less IL17 Expression and More Chlamydial Disease Front Vet Sci. 2020 Sep 25;7:530686. doi: 10.3389/fvets.2020.530686. eCollection 2020. PMID: 33102563 | ||||
A nanovaccine formulation of Chlamydia recombinant MOMP encapsulated in PLGA 85:15 nanoparticles augments CD4(+) effector (CD44(high) CD62L(low)) and memory (CD44(high) CD62L(high)) T-cells in immunized mice Nanomedicine. 2020 Oct;29:102257. doi: 10.1016/j.nano.2020.102257. Epub 2020 Jun 28. PMID: 32610072 | ||||
Protection against a chlamydial respiratory challenge by a chimeric vaccine formulated with the Chlamydia muridarum major outer membrane protein variable domains using the Neisseria lactamica porin B as a scaffold NPJ Vaccines. 2020 May 8;5:37. doi: 10.1038/s41541-020-0182-9. eCollection 2020. PMID: 32411400 | ||||
A Recombinant Chlamydia trachomatis MOMP Vaccine Elicits Cross-serogroup Protection in Mice Against Vaginal Shedding and Infertility J Infect Dis. 2020 Jan 2;221(2):191-200. doi: 10.1093/infdis/jiz438. PMID: 31504647 | ||||
MOMP and MIP DNA-loaded bacterial ghosts reduce the severity of lung lesions in mice after Chlamydia psittaci respiratory tract infection Immunobiology. 2019 Nov;224(6):739-746. doi: 10.1016/j.imbio.2019.09.002. Epub 2019 Sep 6. PMID: 31561842 | ||||
Obtaining an ELISA test based on a recombinant protein of Chlamydia trachomatis Int Microbiol. 2019 Dec;22(4):471-478. doi: 10.1007/s10123-019-00074-4. Epub 2019 Apr 11. PMID: 30976995 | ||||
Therapeutic effect of a Chlamydia pecorum recombinant major outer membrane protein vaccine on ocular disease in koalas (Phascolarctos cinereus) PLoS One. 2019 Jan 7;14(1):e0210245. doi: 10.1371/journal.pone.0210245. eCollection 2019. PMID: 30615687 | ||||
A recombinant multi-epitope peptide vaccine based on MOMP and CPSIT_p6 protein protects against Chlamydia psittaci lung infection Appl Microbiol Biotechnol. 2019 Jan;103(2):941-952. doi: 10.1007/s00253-018-9513-4. Epub 2018 Nov 23. PMID: 30467705 | ||||
CPAF, HSP60 and MOMP antigens elicit pro-inflammatory cytokines production in the peripheral blood mononuclear cells from genital Chlamydia trachomatis-infected patients Immunobiology. 2019 Jan;224(1):34-41. doi: 10.1016/j.imbio.2018.10.010. Epub 2018 Nov 20. PMID: 30477893 | ||||
Spectroscopic analysis of chlamydial major outer membrane protein in support of structure elucidation Protein Sci. 2018 Nov;27(11):1923-1941. doi: 10.1002/pro.3501. PMID: 30144190 | ||||
Predicting tubal factor infertility by using markers of humoral and cell-mediated immune response against Chlamydia trachomatis Am J Reprod Immunol. 2018 Nov;80(5):e13051. doi: 10.1111/aji.13051. Epub 2018 Oct 3. PMID: 30281189 | ||||
Vaccination of koalas (Phascolarctos cinereus) against Chlamydia pecorum using synthetic peptides derived from the major outer membrane protein PLoS One. 2018 Jun 28;13(6):e0200112. doi: 10.1371/journal.pone.0200112. eCollection 2018. PMID: 29953523 | ||||
The bioinformatics analyses reveal novel antigen epitopes in major outer membrane protein of Chlamydia trachomatis Indian J Med Microbiol. 2017 Oct-Dec;35(4):522-528. doi: 10.4103/ijmm.IJMM_17_251. PMID: 29405144 | ||||
Cell-free production of a functional oligomeric form of a Chlamydia major outer-membrane protein (MOMP) for vaccine development J Biol Chem. 2017 Sep 8;292(36):15121-15132. doi: 10.1074/jbc.M117.784561. Epub 2017 Jul 24. PMID: 28739800 | ||||
Pathogenic outcome following experimental infection of sheep with Chlamydia abortus variant strains LLG and POS PLoS One. 2017 May 11;12(5):e0177653. doi: 10.1371/journal.pone.0177653. eCollection 2017. PMID: 28494018 | ||||
Evaluation of tandem Chlamydia trachomatis MOMP multi-epitopes vaccine in BALB/c mice model Vaccine. 2017 May 25;35(23):3096-3103. doi: 10.1016/j.vaccine.2017.04.031. Epub 2017 Apr 26. PMID: 28456528 | ||||
Comparison of the nine polymorphic membrane proteins of Chlamydia trachomatis for their ability to induce protective immune responses in mice against a C. muridarum challenge Vaccine. 2017 May 2;35(19):2543-2549. doi: 10.1016/j.vaccine.2017.03.070. Epub 2017 Apr 3. PMID: 28385608 | ||||
The cationic liposomal adjuvants CAF01 and CAF09 formulated with the major outer membrane protein elicit robust protection in mice against a Chlamydia muridarum respiratory challenge Vaccine. 2017 Mar 23;35(13):1705-1711. doi: 10.1016/j.vaccine.2017.02.020. Epub 2017 Feb 24. PMID: 28238632 | ||||
Protection against genital tract Chlamydia trachomatis infection following intranasal immunization with a novel recombinant MOMP VS2/4 antigen APMIS. 2016 Dec;124(12):1078-1086. doi: 10.1111/apm.12605. PMID: 27859689 | ||||
Recombinant expression of Chlamydia trachomatis major outer membrane protein in E. Coli outer membrane as a substrate for vaccine research BMC Microbiol. 2016 Jul 27;16(1):165. doi: 10.1186/s12866-016-0787-3. PMID: 27464881 | ||||
Characterization of the disulfide bonds and free cysteine residues of the Chlamydia trachomatis mouse pneumonitis major outer membrane protein Biochemistry. 2005 Apr 26;44(16):6250-6. doi: 10.1021/bi047775v. PMID: 15835913 | ||||
Surface expression, single-channel analysis and membrane topology of recombinant Chlamydia trachomatis Major Outer Membrane Protein BMC Microbiol. 2005 Jan 26;5:5. doi: 10.1186/1471-2180-5-5. PMID: 15673471 | ||||
Prediction of the membrane-spanning beta-strands of the major outer membrane protein of Chlamydia Protein Sci. 2002 Jul;11(7):1854-61. doi: 10.1110/ps.3650102. PMID: 12070338 | ||||
Mutagenesis and functional reconstitution of chlamydial major outer membrane proteins: VS4 domains are not required for pore formation but modify channel function Infect Immun. 2001 Mar;69(3):1671-8. doi: 10.1128/IAI.69.3.1671-1678.2001. PMID: 11179342 | ||||
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