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Members of this family are found in many Borrelia species. They are large outer membrane proteins that exhibit porin activity in planar lipid bilayers. The average single-channel conductance predicts a rather large pore diameter of 2.6 nm. The exact number of transmembrane strands is unknown but prediction methods suggest a large number, which is in agreement with the large pore. There is evidence that the C-terminal region may traverse through the channel and be surface-accessible. There are also indications that native Oms66 can elicit potent bactericidal activity and significant protective immunity against host-adapted organisms.
The Oms66 (p66) protein is a Borrelia burgdorferi porin
Infect Immun. 1997 Sep;65(9):3654-61. doi: 10.1128/IAI.65.9.3654-3661.1997.
Protection elicited by native outer membrane protein Oms66 (p66) against host-adapted Borrelia burgdorferi: conformational nature of bactericidal epitopes
Infect Immun. 2000 May;68(5):2647-54. doi: 10.1128/iai.68.5.2647-2654.2000.
A surface-exposed region of a novel outer membrane protein (P66) of Borrelia spp. is variable in size and sequence
J Bacteriol. 1998 Apr;180(7):1618-23. doi: 10.1128/JB.180.7.1618-1623.1998.