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The Borrelia Oms66/Omp66 Family [Function: Non-specific channels] Seed alignment | Full alignment in OMPdb | |
Members of this family are found in many Borrelia species. They are large outer membrane proteins that exhibit porin activity in planar lipid bilayers. The average single-channel conductance predicts a rather large pore diameter of 2.6 nm. The exact number of transmembrane strands is unknown but prediction methods suggest a large number, which is in agreement with the large pore. There is evidence that the C-terminal region may traverse through the channel and be surface-accessible. There are also indications that native Oms66 can elicit potent bactericidal activity and significant protective immunity against host-adapted organisms. | |
Literature references | |
The Oms66 (p66) protein is a Borrelia burgdorferi porin Infect Immun. 1997 Sep;65(9):3654-61. doi: 10.1128/IAI.65.9.3654-3661.1997. PMID: 9284133 | |
Protection elicited by native outer membrane protein Oms66 (p66) against host-adapted Borrelia burgdorferi: conformational nature of bactericidal epitopes Infect Immun. 2000 May;68(5):2647-54. doi: 10.1128/iai.68.5.2647-2654.2000. PMID: 10768956 | |
A surface-exposed region of a novel outer membrane protein (P66) of Borrelia spp. is variable in size and sequence J Bacteriol. 1998 Apr;180(7):1618-23. doi: 10.1128/JB.180.7.1618-1623.1998. PMID: 9537355 |
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