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The Borrelia Oms66/Omp66 Family [Function: Non-specific channels] Seed alignment | Full alignment in OMPdb

Members of this family are found in many Borrelia species. They are large outer membrane proteins that exhibit porin activity in planar lipid bilayers. The average single-channel conductance predicts a rather large pore diameter of 2.6 nm. The exact number of transmembrane strands is unknown but prediction methods suggest a large number, which is in agreement with the large pore. There is evidence that the C-terminal region may traverse through the channel and be surface-accessible. There are also indications that native Oms66 can elicit potent bactericidal activity and significant protective immunity against host-adapted organisms.

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Literature references

The Oms66 (p66) protein is a Borrelia burgdorferi porin
Infect Immun. 1997 Sep;65(9):3654-61. doi: 10.1128/IAI.65.9.3654-3661.1997.
PMID: 9284133

Protection elicited by native outer membrane protein Oms66 (p66) against host-adapted Borrelia burgdorferi: conformational nature of bactericidal epitopes
Infect Immun. 2000 May;68(5):2647-54. doi: 10.1128/iai.68.5.2647-2654.2000.
PMID: 10768956

A surface-exposed region of a novel outer membrane protein (P66) of Borrelia spp. is variable in size and sequence
J Bacteriol. 1998 Apr;180(7):1618-23. doi: 10.1128/JB.180.7.1618-1623.1998.
PMID: 9537355

Elixir UTH dib compgen