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The Brucella-Rhizobium Porin (BRP) Family [Function: Non-specific channels] Seed alignment | Full alignment in OMPdb

This family consists of several outer membrane proteins (Omp2a and Omp2b) from Brucella species. Other homologs are found in Agrobacterium, Bartonella, Mesorhizobium and Rhizobium. Omp2a and Omp2b are predicted to constitute ß-barrels, with the variable regions placed in the outer loops. Sequence variation in these proteins seems to result mainly in porin conductivity modifications, since variants show different permeability to sugars along with different ion conductivities.

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Literature references

Phenotypic and molecular characterization of a Brucella strain isolated from a minke whale (Balaenoptera acutorostrata)
Microbiology (Reading). 1998 Dec;144 ( Pt 12):3267-73. doi: 10.1099/00221287-144-12-3267.
PMID: 9884218

Major outer membrane proteins of Brucella spp.: past, present and future
Vet Microbiol. 2002 Dec 20;90(1-4):229-47. doi: 10.1016/s0378-1135(02)00211-0.
PMID: 12414146

Molecular, antigenic, and functional analyses of Omp2b porin size variants of Brucella spp
J Bacteriol. 2001 Aug;183(16):4839-47. doi: 10.1128/JB.183.16.4839-4847.2001.
PMID: 11466287

Topology prediction of Brucella abortus Omp2b and Omp2a porins after critical assessment of transmembrane beta strands prediction by several secondary structure prediction methods
J Biomol Struct Dyn. 2000 Feb;17(4):747-57. doi: 10.1080/07391102.2000.10506564.
PMID: 10698111

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