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The Brucella outer membrane protein 2 Family [Function: Non-specific diffusion channels] Seed alignment | Full alignment | Pfam page | TC-DB page | ||||
This family consists of several outer membrane proteins (Omp2a and Omp2b) from Brucella species. Other homologs are found in Agrobacterium, Bartonella, Mesorhizobium and Rhizobium. Omp2a and Omp2b are predicted to constitute ß-barrels, with the variable regions placed in the outer loops. Omp2a emerges as a potential antigen candidate for serodiagnosis of human brucellosis. Sequence variation in these proteins seems to result mainly in porin conductivity modifications, since variants show different permeability to sugars along with different ion conductivities. | ||||
| Literature references | ||||
A novel recombinant multiepitope protein candidate for the diagnosis of brucellosis: A pilot study J Microbiol Methods. 2020 Jul;174:105964. doi: 10.1016/j.mimet.2020.105964. Epub 2020 May 30. PMID: 32479870 | ||||
Omp2b Porin Alteration in the Course of Evolution of Brucella spp Front Microbiol. 2020 Feb 24;11:284. doi: 10.3389/fmicb.2020.00284. eCollection 2020. PMID: 32153552 | ||||
Immunoinformatics prediction of OMP2b and BCSP31 for designing multi-epitope vaccine against Brucella Mol Immunol. 2019 Oct;114:651-660. doi: 10.1016/j.molimm.2019.09.013. Epub 2019 Sep 23. PMID: 31557626 | ||||
Recombinant Omp2b antigen-based ELISA is an efficient tool for specific serodiagnosis of animal brucellosis Braz J Microbiol. 2019 Oct;50(4):979-984. doi: 10.1007/s42770-019-00097-z. Epub 2019 Jul 27. PMID: 31352634 | ||||
Localized incorporation of outer membrane components in the pathogen Brucella abortus EMBO J. 2019 Mar 1;38(5):e100323. doi: 10.15252/embj.2018100323. Epub 2019 Jan 11. PMID: 30635335 | ||||
3D structure of a Brucella melitensis porin: molecular modelling in lipid membranes J Biomol Struct Dyn. 2019 Sep;37(15):3923-3935. doi: 10.1080/07391102.2018.1529627. Epub 2018 Dec 28. PMID: 30593262 | ||||
Properties of Omp2a-Based Supported Lipid Bilayers: Comparison with Polymeric Bioinspired Membranes ACS Omega. 2018 Aug 13;3(8):9003-9019. doi: 10.1021/acsomega.8b00913. eCollection 2018 Aug 31. PMID: 31459033 | ||||
Evaluation of recombinant porin (rOmp2a) protein as a potential antigen candidate for serodiagnosis of Human Brucellosis BMC Infect Dis. 2017 Jul 11;17(1):485. doi: 10.1186/s12879-017-2588-1. PMID: 28693438 | ||||
Protein/Protein, DNA/DNA and DNA/Protein based vaccination strategies using truncated Omp2b against Brucella infection in BALB/c Mice Int J Med Microbiol. 2017 Jun;307(4-5):249-256. doi: 10.1016/j.ijmm.2017.03.004. Epub 2017 Mar 28. PMID: 28391992 | ||||
Comparison of potential protection conferred by three immunization strategies (protein/protein, DNA/DNA, and DNA/protein) against Brucella infection using Omp2b in BALB/c Mice Vet Microbiol. 2016 Dec 25;197:47-52. doi: 10.1016/j.vetmic.2016.10.027. Epub 2016 Nov 5. PMID: 27938682 | ||||
Confinement of a ß-barrel protein in nanoperforated free-standing nanomembranes for ion transport Nanoscale. 2016 Sep 29;8(38):16922-16935. doi: 10.1039/c6nr04948f. PMID: 27714137 | ||||
In silico analysis of Brucella abortus Omp2b and in vitro expression of SOmp2b Clin Exp Vaccine Res. 2016 Jan;5(1):75-82. doi: 10.7774/cevr.2016.5.1.75. Epub 2016 Jan 27. PMID: 26866027 | ||||
Polypyrrole-supported membrane proteins for bio-inspired ion channels ACS Appl Mater Interfaces. 2015 Jan 28;7(3):1632-43. doi: 10.1021/am507142f. Epub 2015 Jan 13. PMID: 25585165 | ||||
Towards a universal method for protein refolding: the trimeric beta barrel membrane Omp2a as a test case Biotechnol Bioeng. 2013 Feb;110(2):417-23. doi: 10.1002/bit.24722. Epub 2012 Sep 18. PMID: 22949228 | ||||
Purification, refolding and characterization of the trimeric Omp2a outer membrane porin from Brucella melitensis Protein Expr Purif. 2012 Jun;83(2):198-204. doi: 10.1016/j.pep.2012.04.003. Epub 2012 Apr 17. PMID: 22538317 | ||||
Major outer membrane proteins of Brucella spp.: past, present and future Vet Microbiol. 2002 Dec 20;90(1-4):229-47. doi: 10.1016/s0378-1135(02)00211-0. PMID: 12414146 | ||||
Molecular, antigenic, and functional analyses of Omp2b porin size variants of Brucella spp J Bacteriol. 2001 Aug;183(16):4839-47. doi: 10.1128/JB.183.16.4839-4847.2001. PMID: 11466287 | ||||
Topology prediction of Brucella abortus Omp2b and Omp2a porins after critical assessment of transmembrane beta strands prediction by several secondary structure prediction methods J Biomol Struct Dyn. 2000 Feb;17(4):747-57. doi: 10.1080/07391102.2000.10506564. PMID: 10698111 | ||||
Phenotypic and molecular characterization of a Brucella strain isolated from a minke whale (Balaenoptera acutorostrata) Microbiology (Reading). 1998 Dec;144 ( Pt 12):3267-73. doi: 10.1099/00221287-144-12-3267. PMID: 9884218 | ||||
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