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The Brucella outer membrane protein 2 Family [Function: Non-specific diffusion channels] Seed alignment | Full alignment | Pfam page | TC-DB page

This family consists of several outer membrane proteins (Omp2a and Omp2b) from Brucella species. Other homologs are found in Agrobacterium, Bartonella, Mesorhizobium and Rhizobium. Omp2a and Omp2b are predicted to constitute ß-barrels, with the variable regions placed in the outer loops. Omp2a emerges as a potential antigen candidate for serodiagnosis of human brucellosis. Sequence variation in these proteins seems to result mainly in porin conductivity modifications, since variants show different permeability to sugars along with different ion conductivities.

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Literature references

A novel recombinant multiepitope protein candidate for the diagnosis of brucellosis: A pilot study
J Microbiol Methods. 2020 Jul;174:105964. doi: 10.1016/j.mimet.2020.105964. Epub 2020 May 30.
PMID: 32479870

Omp2b Porin Alteration in the Course of Evolution of Brucella spp
Front Microbiol. 2020 Feb 24;11:284. doi: 10.3389/fmicb.2020.00284. eCollection 2020.
PMID: 32153552

Immunoinformatics prediction of OMP2b and BCSP31 for designing multi-epitope vaccine against Brucella
Mol Immunol. 2019 Oct;114:651-660. doi: 10.1016/j.molimm.2019.09.013. Epub 2019 Sep 23.
PMID: 31557626

Recombinant Omp2b antigen-based ELISA is an efficient tool for specific serodiagnosis of animal brucellosis
Braz J Microbiol. 2019 Oct;50(4):979-984. doi: 10.1007/s42770-019-00097-z. Epub 2019 Jul 27.
PMID: 31352634

Localized incorporation of outer membrane components in the pathogen Brucella abortus
EMBO J. 2019 Mar 1;38(5):e100323. doi: 10.15252/embj.2018100323. Epub 2019 Jan 11.
PMID: 30635335

3D structure of a Brucella melitensis porin: molecular modelling in lipid membranes
J Biomol Struct Dyn. 2019 Sep;37(15):3923-3935. doi: 10.1080/07391102.2018.1529627. Epub 2018 Dec 28.
PMID: 30593262

Properties of Omp2a-Based Supported Lipid Bilayers: Comparison with Polymeric Bioinspired Membranes
ACS Omega. 2018 Aug 13;3(8):9003-9019. doi: 10.1021/acsomega.8b00913. eCollection 2018 Aug 31.
PMID: 31459033

Evaluation of recombinant porin (rOmp2a) protein as a potential antigen candidate for serodiagnosis of Human Brucellosis
BMC Infect Dis. 2017 Jul 11;17(1):485. doi: 10.1186/s12879-017-2588-1.
PMID: 28693438

Protein/Protein, DNA/DNA and DNA/Protein based vaccination strategies using truncated Omp2b against Brucella infection in BALB/c Mice
Int J Med Microbiol. 2017 Jun;307(4-5):249-256. doi: 10.1016/j.ijmm.2017.03.004. Epub 2017 Mar 28.
PMID: 28391992

Comparison of potential protection conferred by three immunization strategies (protein/protein, DNA/DNA, and DNA/protein) against Brucella infection using Omp2b in BALB/c Mice
Vet Microbiol. 2016 Dec 25;197:47-52. doi: 10.1016/j.vetmic.2016.10.027. Epub 2016 Nov 5.
PMID: 27938682

Confinement of a ß-barrel protein in nanoperforated free-standing nanomembranes for ion transport
Nanoscale. 2016 Sep 29;8(38):16922-16935. doi: 10.1039/c6nr04948f.
PMID: 27714137

In silico analysis of Brucella abortus Omp2b and in vitro expression of SOmp2b
Clin Exp Vaccine Res. 2016 Jan;5(1):75-82. doi: 10.7774/cevr.2016.5.1.75. Epub 2016 Jan 27.
PMID: 26866027

Polypyrrole-supported membrane proteins for bio-inspired ion channels
ACS Appl Mater Interfaces. 2015 Jan 28;7(3):1632-43. doi: 10.1021/am507142f. Epub 2015 Jan 13.
PMID: 25585165

Towards a universal method for protein refolding: the trimeric beta barrel membrane Omp2a as a test case
Biotechnol Bioeng. 2013 Feb;110(2):417-23. doi: 10.1002/bit.24722. Epub 2012 Sep 18.
PMID: 22949228

Purification, refolding and characterization of the trimeric Omp2a outer membrane porin from Brucella melitensis
Protein Expr Purif. 2012 Jun;83(2):198-204. doi: 10.1016/j.pep.2012.04.003. Epub 2012 Apr 17.
PMID: 22538317

Major outer membrane proteins of Brucella spp.: past, present and future
Vet Microbiol. 2002 Dec 20;90(1-4):229-47. doi: 10.1016/s0378-1135(02)00211-0.
PMID: 12414146

Molecular, antigenic, and functional analyses of Omp2b porin size variants of Brucella spp
J Bacteriol. 2001 Aug;183(16):4839-47. doi: 10.1128/JB.183.16.4839-4847.2001.
PMID: 11466287

Topology prediction of Brucella abortus Omp2b and Omp2a porins after critical assessment of transmembrane beta strands prediction by several secondary structure prediction methods
J Biomol Struct Dyn. 2000 Feb;17(4):747-57. doi: 10.1080/07391102.2000.10506564.
PMID: 10698111

Phenotypic and molecular characterization of a Brucella strain isolated from a minke whale (Balaenoptera acutorostrata)
Microbiology (Reading). 1998 Dec;144 ( Pt 12):3267-73. doi: 10.1099/00221287-144-12-3267.
PMID: 9884218

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