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Production of cellulose has been initially observed in Acetobacter xylinum. Recent studies though have shown that besides thin aggregative fimbriae, the second component of the extracellular matrix of the multicellular morphotype (rdar) of Salmonella typhimurium and Escherichia coli is cellulose. BcsC is a member of this cellulose synthase operon composed also by BcsA, BcsB and BcsD genes. Mutants in the BcsC and BcsD genes were impaired in cellulose production in vivo, even though they had the capacity to make all the necessary metabolic precursors and cyclic diguanylic acid, the activator of cellulose synthase, and exhibit cellulose synthase activity in vitro. Recently, a proteomics analysis of Erwinia chrysanthemi, revealed that BcsC is located in the outer membrane. The postulated ß-barrel domain is located in the C-terminal of the protein and probably serves as a membrane anchoring region or a channel for cellulose export. Other domains are also found in the rest of the protein, including several tetratricopeptide repeat (TPR) domains, responsible for protein-protein interactions.
Architecture of the Cellulose Synthase Outer Membrane Channel and Its Association with the Periplasmic TPR Domain
Structure. 2019 Dec 3;27(12):1855-1861.e3. doi: 10.1016/j.str.2019.09.008. Epub 2019 Oct 8.
Crystal structure of the flexible tandem repeat domain of bacterial cellulose synthesis subunit C
Sci Rep. 2017 Oct 12;7(1):13018. doi: 10.1038/s41598-017-12530-0.
Proteomic analysis of the carbonate insoluble outer membrane fraction of the soft-rot pathogen Dickeya dadantii (syn. Erwinia chrysanthemi) strain 3937
J Proteome Res. 2007 Jan;6(1):62-9. doi: 10.1021/pr060423l.
The multicellular morphotypes of Salmonella typhimurium and Escherichia coli produce cellulose as the second component of the extracellular matrix
Mol Microbiol. 2001 Mar;39(6):1452-63. doi: 10.1046/j.1365-2958.2001.02337.x.
Genetic organization of the cellulose synthase operon in Acetobacter xylinum
Proc Natl Acad Sci U S A. 1990 Oct;87(20):8130-4. doi: 10.1073/pnas.87.20.8130.
|Proteins in this family with 3D-structure|
Vitamin B12 transporter BtuB
Escherichia coli (strain K12)