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The Borrelia Oms28 porin Family [Function: Non-specific channels] Seed alignment | Full alignment in OMPdb

Members of this family are small (28 kDa) surface exposed proteins found in Borrelia. They exhibit channel activity, which indicates their role as porins. However, prediction methods do not corroborate to a large beta sheet content, a fact that may indicates the multimeric nature of the presumable ß-barrel. Recent contradicting evidence though suggest that Oms28 could be a periplasmic outer membrane-associated protein.

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Literature references

Porin activity of the native and recombinant outer membrane protein Oms28 of Borrelia burgdorferi
J Bacteriol. 1996 Aug;178(16):4909-18. doi: 10.1128/jb.178.16.4909-4918.1996.
PMID: 8759855

Borrelia burgdorferi BBA74, a periplasmic protein associated with the outer membrane, lacks porin-like properties
J Bacteriol. 2007 Mar;189(5):2063-8. doi: 10.1128/JB.01239-06. Epub 2006 Dec 22.
PMID: 17189354

Borrelia burgdorferi bba74 is expressed exclusively during tick feeding and is regulated by both arthropod- and mammalian host-specific signals
J Bacteriol. 2009 Apr;191(8):2783-94. doi: 10.1128/JB.01802-08. Epub 2009 Feb 13.
PMID: 19218390

Elixir UTH dib compgen