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The Glucose-selective OprB Porin (OprB) Family [Function: Specific channels] Seed alignment | Full alignment in OMPdb

The OprB family includes the Pseudomonas aeruginosa porin B (OprB), a substrate-selective channel for a variety of different sugars, which is probably restricted to carbohydrates and facilitates glucose fusion across the outer membrane. Homologs are also found in Pseudomonas chlororaphis, Burkholderia cepacia, Pseudomonas fluorescens, Acinetobacter calcoaceticus and Xanthomonas campestris. The high-affinity glucose transport system is primarily specific for glucose and well conserved, although the outer membrane components may differ in channel architecture and specificity for other carbohydrates. Similar to other porins, these proteins form 16-stranded beta barrels.

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Literature references

Multiple environmental factors regulate the expression of the carbohydrate-selective OprB porin of Pseudomonas aeruginosa
Can J Microbiol. 1999 Dec;45(12):1033-42.
PMID: 10696483

Channel specificity and secondary structure of the glucose-inducible porins of Pseudomonas spp
J Bioenerg Biomembr. 1998 Jun;30(3):257-67. doi: 10.1023/a:1020596820314.
PMID: 9733092

The OprB porin plays a central role in carbohydrate uptake in Pseudomonas aeruginosa
J Bacteriol. 1995 Jun;177(11):3021-6. doi: 10.1128/jb.177.11.3021-3026.1995.
PMID: 7768797

Cloning and nucleotide sequence of the Pseudomonas aeruginosa glucose-selective OprB porin gene and distribution of OprB within the family Pseudomonadaceae
Eur J Biochem. 1994 Mar 1;220(2):505-12. doi: 10.1111/j.1432-1033.1994.tb18649.x.
PMID: 8125108

Proteins in this family with 3D-structure


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