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This family consists of several proteins found in various pathogenic bacteria. The prototype of the family, SfpA of Yersinia enterocolitica, is heat modifiable, which has been detected in the membrane fraction after fractionization. Analysis of bacterial colonization revealed that a {Delta} SfpA strain is defective in mesenteric lymph node colonization. A very close homolog, has been designated as the lipid A-3-O deacylase (LpxR) that has been identified in the outer membrane of Salmonella typhimurium. Its strucure has been solved and suggests a ß-barrel of 12 ß strands. | ||||
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| Literature references | ||||
Helicobacter pylori Resists the Antimicrobial Activity of Calprotectin via Lipid A Modification and Associated Biofilm Formation mBio. 2015 Dec 8;6(6):e01349-15. doi: 10.1128/mBio.01349-15. PMID: 26646009 | ||||
Lipid A 3'-O-deacylation by Salmonella outer membrane enzyme LpxR modulates the ability of lipid A to stimulate Toll-like receptor 4 Biochem Biophys Res Commun. 2012 Nov 23;428(3):343-7. doi: 10.1016/j.bbrc.2012.10.054. Epub 2012 Oct 22. PMID: 23085233 | ||||
Phosphate groups of lipid A are essential for Salmonella enterica serovar Typhimurium virulence and affect innate and adaptive immunity Infect Immun. 2012 Sep;80(9):3215-24. doi: 10.1128/IAI.00123-12. Epub 2012 Jul 2. PMID: 22753374 | ||||
Palmitoylation state impacts induction of innate and acquired immunity by the Salmonella enterica serovar typhimurium msbB mutant Infect Immun. 2011 Dec;79(12):5027-38. doi: 10.1128/IAI.05524-11. Epub 2011 Sep 19. PMID: 21930761 | ||||
Active-site architecture and catalytic mechanism of the lipid A deacylase LpxR of Salmonella typhimurium Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1960-4. doi: 10.1073/pnas.0813064106. Epub 2009 Jan 27. PMID: 19174515 | ||||
Structural biology of membrane-intrinsic beta-barrel enzymes: sentinels of the bacterial outer membrane Biochim Biophys Acta. 2008 Sep;1778(9):1881-96. doi: 10.1016/j.bbamem.2007.07.021. Epub 2007 Aug 11. PMID: 17880914 | ||||
Characterization of a novel porin involved in systemic Yersinia enterocolitica infection Infect Immun. 2006 Jul;74(7):4361-5. doi: 10.1128/IAI.00154-06. PMID: 16790812 | ||||
An outer membrane enzyme encoded by Salmonella typhimurium lpxR that removes the 3'-acyloxyacyl moiety of lipid A J Biol Chem. 2006 Aug 4;281(31):21974-21987. doi: 10.1074/jbc.M603527200. Epub 2006 May 16. PMID: 16704973 | ||||
| Proteins in this family with 3D-structure | ||||
View Entry | Description | Organism | Length | # strands |