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The Sugar Porin (SP) Family [Function: Specific channels] Seed alignment | Full alignment in OMPdb

This family includes the well characterized maltoporins of Escherichia coli and Salmonella typhimurium as well as the sucrose-specific porin of Salmonella typhimurium, whose 3D structures have been resolved by X-ray diffraction. These porins form trimers but, in contrast to proteins belonging to other bacterial porin families which consist of 16 beta-stranded ß-barrels, they consist of an 18 beta-stranded ß-barrel. Despite the wider barrel compared to other porins, sugar-specific porins exhibit a narrower channel, showing only a small fraction of the ionic conductance of the latter porins. There is also evidence that in most cases, the N-terminal residues form a coiled-coil of alpha helices facilitating low-affinity sugar binding and supramolecular stabilisation.

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Literature references

Structure and functional characterization of the periplasmic N-terminal polypeptide domain of the sugar-specific ion channel protein (ScrY porin)
Protein Sci. 2002 Jun;11(6):1565-74. doi: 10.1110/ps.2760102.
PMID: 12021455

Crystallization and preliminary X-ray diffraction analysis of ScrY, a specific bacterial outer membrane porin
J Mol Biol. 1993 Jan 5;229(1):258-62. doi: 10.1006/jmbi.1993.1028.
PMID: 8421311

Structural basis for sugar translocation through maltoporin channels at 3.1 A resolution
Science. 1995 Jan 27;267(5197):512-4. doi: 10.1126/science.7824948.
PMID: 7824948

Channel specificity: structural basis for sugar discrimination and differential flux rates in maltoporin
J Mol Biol. 1997 Sep 12;272(1):56-63. doi: 10.1006/jmbi.1997.1224.
PMID: 9299337

Structure of the sucrose-specific porin ScrY from Salmonella typhimurium and its complex with sucrose
Nat Struct Biol. 1998 Jan;5(1):37-46. doi: 10.1038/nsb0198-37.
PMID: 9437428

Structure of maltoporin from Salmonella typhimurium ligated with a nitrophenyl-maltotrioside
J Mol Biol. 1997 Mar 7;266(4):761-75. doi: 10.1006/jmbi.1996.0823.
PMID: 9102468

Proteins in this family with 3D-structure




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