Browse Text search Protein search Domain search Download User manual Related links Citation & Contact

The Copper resistance protein B precursor (CopB) Family [Function: Specific diffusion channels] Seed alignment | Full alignment | Pfam page | TC-DB page

This family consists of several bacterial copper resistance proteins. Copper is essential as it serves as co-factor for a variety of enzymes. However, excess of copper is toxic and leads to radical formation and oxidation of biomolecules. CopB serves to extrude copper when it approaches toxic levels. The protein CopB is located in the outer membrane, and seems to form a ß-barrel. The relatively small N-terminal domain is predicted to be periplasmic, suggesting a structural resemblance with TonB dependent receptors, however no sequence homology is apparent.

Specify pHMMs' % coverageUnspecified More than   

Literature references

Biochemical and localization analyses of putative type III secretion translocator proteins CopB and CopB2 of Chlamydia trachomatis reveal significant distinctions
Infect Immun. 2011 Aug;79(8):3036-45. doi: 10.1128/IAI.00159-11. Epub 2011 May 23.
PMID: 21606186

Molecular characterization of copper resistance genes from Xanthomonas citri subsp. citri and Xanthomonas alfalfae subsp. citrumelonis
Appl Environ Microbiol. 2011 Jun;77(12):4089-96. doi: 10.1128/AEM.03043-10. Epub 2011 Apr 22.
PMID: 21515725

Polymorphism of the major surface epitope of the CopB outer membrane protein of Moraxella catarrhalis
FEMS Immunol Med Microbiol. 2006 Aug;47(3):343-50. doi: 10.1111/j.1574-695X.2006.00093.x.
PMID: 16872370

Tetrathiomolybdate inhibition of the Enterococcus hirae CopB copper ATPase
FEBS Lett. 2001 Nov 2;507(3):367-70. doi: 10.1016/s0014-5793(01)03009-5.
PMID: 11696373

Characterization of chromosomal homologs of the plasmid-borne copper resistance operon of Pseudomonas syringae
J Bacteriol. 1993 Jul;175(14):4492-8. doi: 10.1128/jb.175.14.4492-4498.1993.
PMID: 8331076

Copper resistance in Pseudomonas syringae mediated by periplasmic and outer membrane proteins
Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):8915-9. doi: 10.1073/pnas.88.20.8915.
PMID: 1924351

Elixir UTH dib compgen