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The MipA/OmpV Family [Function: Structural] Seed alignment | Full alignment in OMPdb

This family consists mainly of homologs to MipA and OmpV proteins. In addition to interacting with the membrane-bound lytic transglycosylase MltA, MipA is known to bind to PBP1B, a bifunctional murein transglycosylase/transpeptidase. MipA is considered to be a structural protein mediating the assembly of MltA to PBP1B into a complex. OmpV, is the Major Outer Membrane Protein (MOMP) of Vibrio cholerae. Proteins of this family, are predicted to form a ß-barrel.

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Literature references

Demonstration of molecular interactions between the murein polymerase PBP1B, the lytic transglycosylase MltA, and the scaffolding protein MipA of Escherichia coli
J Biol Chem. 1999 Mar 5;274(10):6726-34. doi: 10.1074/jbc.274.10.6726.
PMID: 10037771

Proteomic analysis of salt-sensitive outer membrane proteins of Vibrio parahaemolyticus
Res Microbiol. 2004 Dec;155(10):835-42. doi: 10.1016/j.resmic.2004.07.001.
PMID: 15567278

Nucleotide sequence of ompV, the gene for a major Vibrio cholerae outer membrane protein
Mol Gen Genet. 1986 Dec;205(3):494-500. doi: 10.1007/BF00338088.
PMID: 3031428

Proteomic analysis of the Escherichia coli outer membrane
Eur J Biochem. 2000 May;267(10):2871-81. doi: 10.1046/j.1432-1327.2000.01296.x.
PMID: 10806384

Molecular analysis of porin gene transcription in heterogenotypic multidrug-resistant Escherichia coli isolates from scouring calves
J Antimicrob Chemother. 2010 Sep;65(9):1926-35. doi: 10.1093/jac/dkq246. Epub 2010 Jul 17.
PMID: 20639525

Outer membrane proteome and its regulation networks in response to glucose concentration changes in Escherichia coli
Mol Biosyst. 2011 Nov;7(11):3087-93. doi: 10.1039/c1mb05193h. Epub 2011 Aug 18.
PMID: 21850335

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