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The MltA-interacting protein (MipA) Family [Function: Adhesion] Seed alignment | Full alignment | Pfam page | TC-DB page

This family consists mainly of homologs to MipA and OmpV proteins. In addition to interacting with the membrane-bound lytic transglycosylase MltA, MipA is known to bind to PBP1B, a bifunctional murein transglycosylase/transpeptidase. MipA is considered to be a structural protein mediating the assembly of MltA to PBP1B into a complex. Further, MipA was a novel OM protein related to antibiotic resistance. OmpV, is the Major Outer Membrane Protein (MOMP) of Vibrio cholerae. Proteins of this family, are predicted to form a ß-barrel.

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Literature references

Outer membrane protein OmpV mediates Salmonella enterica serovar typhimurium adhesion to intestinal epithelial cells via fibronectin and ?1ß1 integrin
Cell Microbiol. 2020 May;22(5):e13172. doi: 10.1111/cmi.13172. Epub 2020 Feb 10.
PMID: 32017350

Vesicles From Vibrio cholerae Contain AT-Rich DNA and Shorter mRNAs That Do Not Correlate With Their Protein Products
Front Microbiol. 2019 Nov 22;10:2708. doi: 10.3389/fmicb.2019.02708. eCollection 2019.
PMID: 31824470

The Immune Adjuvant Effects of Flounder (Paralichthys olivaceus) Interleukin-6 on E. tarda Subunit Vaccine OmpV
Int J Mol Sci. 2017 Jul 5;18(7):1445. doi: 10.3390/ijms18071445.
PMID: 28678171

Analysis and Characterization of Proteins Associated with Outer Membrane Vesicles Secreted by Cronobacter spp
Front Microbiol. 2017 Feb 9;8:134. doi: 10.3389/fmicb.2017.00134. eCollection 2017.
PMID: 28232819

Immunization with the MipA, Skp, or ETEC_2479 Antigens Confers Protection against Enterotoxigenic E. coli Strains Expressing Different Colonization Factors in a Mouse Pulmonary Challenge Model
Front Cell Infect Microbiol. 2016 Dec 12;6:181. doi: 10.3389/fcimb.2016.00181. eCollection 2016.
PMID: 28018863

Outer membrane proteomics of kanamycin-resistant Escherichia coli identified MipA as a novel antibiotic resistance-related protein
FEMS Microbiol Lett. 2015 Jun;362(11):fnv074. doi: 10.1093/femsle/fnv074. Epub 2015 May 3.
PMID: 25940639

Identification of Outer Membrane Proteins Altered in Response to UVC-Radiation in Vibrio parahaemolyticus and Vibrio alginolyticus
Indian J Microbiol. 2012 Dec;52(4):660-5. doi: 10.1007/s12088-012-0299-2. Epub 2012 Sep 4.
PMID: 24293727

Outer membrane proteome and its regulation networks in response to glucose concentration changes in Escherichia coli
Mol Biosyst. 2011 Nov;7(11):3087-93. doi: 10.1039/c1mb05193h. Epub 2011 Aug 18.
PMID: 21850335

Molecular analysis of porin gene transcription in heterogenotypic multidrug-resistant Escherichia coli isolates from scouring calves
J Antimicrob Chemother. 2010 Sep;65(9):1926-35. doi: 10.1093/jac/dkq246. Epub 2010 Jul 17.
PMID: 20639525

Proteomic analysis of salt-sensitive outer membrane proteins of Vibrio parahaemolyticus
Res Microbiol. 2004 Dec;155(10):835-42. doi: 10.1016/j.resmic.2004.07.001.
PMID: 15567278

Proteomic analysis of the Escherichia coli outer membrane
Eur J Biochem. 2000 May;267(10):2871-81. doi: 10.1046/j.1432-1327.2000.01296.x.
PMID: 10806384

Demonstration of molecular interactions between the murein polymerase PBP1B, the lytic transglycosylase MltA, and the scaffolding protein MipA of Escherichia coli
J Biol Chem. 1999 Mar 5;274(10):6726-34. doi: 10.1074/jbc.274.10.6726.
PMID: 10037771

Nucleotide sequence of ompV, the gene for a major Vibrio cholerae outer membrane protein
Mol Gen Genet. 1986 Dec;205(3):494-500. doi: 10.1007/BF00338088.
PMID: 3031428

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