This family includes homologs to the OprF of Pseudomonas aeruginosa. Members of this family (similar to members of the OmpA family) show a modular architecture, composed of two distinct Structural domains: an N-terminal ß-barrel domain with short turns at the periplasmic ends and long flexible loops at the external ends that anchor the protein to the outer membrane; and a C-terminal domain that protrudes into the periplasmic space interacting with peptidoglycans. The C-terminal domain (named OmpA-like domain), is also found in a number of outer membrane lipoproteins, therefore it is not characteristic of ß-barrels. There is also a distant homology to members of the OmpW family. A recently solved structure reveals a barrel with 8 ß strands.

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