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The Opacity porin protein Family [Function: Adhesion] Seed alignment | Full alignment | Pfam page | Pfam Wiki page

Members of this family are homologs to the surface protein A (NspA) from Neisseria meningitidis, which is a promising vaccine candidate. NspA is a highly conserved membrane protein that elicits protective antibody responses in mice against Neisseria meningitidis infection. NspA forms an 8-stranded antiparallel ß-barrel, whereas the four loops at the extracellular side of the NspA molecule form a long cleft, which contains mainly hydrophobic residues and harbors a detergent molecule, suggesting that the protein might function in the binding of hydrophobic ligands, such as lipids. Loops 2 and 3, are more important regarding antibody binding.


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Literature references


A homopolymeric adenosine tract in the promoter region of nspA influences factor H-mediated serum resistance in Neisseria meningitidis
Sci Rep. 2019 Feb 25;9(1):2736. doi: 10.1038/s41598-019-39231-0.
PMID: 30804422

Role of Gonococcal Neisserial Surface Protein A (NspA) in Serum Resistance and Comparison of Its Factor H Binding Properties with Those of Its Meningococcal Counterpart
Infect Immun. 2019 Jan 24;87(2):e00658-18. doi: 10.1128/IAI.00658-18. Print 2019 Feb.
PMID: 30510105

Impaired Immunogenicity of Meningococcal Neisserial Surface Protein A in Human Complement Factor H Transgenic Mice
Infect Immun. 2015 Nov 23;84(2):452-8. doi: 10.1128/IAI.01267-15. Print 2016 Feb.
PMID: 26597984

Binding of complement factor H to PorB3 and NspA enhances resistance of Neisseria meningitidis to anti-factor H binding protein bactericidal activity
Infect Immun. 2015 Apr;83(4):1536-45. doi: 10.1128/IAI.02984-14. Epub 2015 Feb 2.
PMID: 25644002

Recombinant Neisseria surface protein A is a potential vaccine candidate against Neisseria meningitides serogroup B
Mol Med Rep. 2014 Sep;10(3):1619-25. doi: 10.3892/mmr.2014.2325. Epub 2014 Jun 13.
PMID: 24926810

nspA gene as a specific genetic marker for detection of Neisseria meningitidis causing bacterial meningitis
Indian J Biochem Biophys. 2014 Jun;51(3):211-4.
PMID: 25204083

fH-dependent complement evasion by disease-causing meningococcal strains with absent fHbp genes or frameshift mutations
Vaccine. 2013 Aug 28;31(38):4192-9. doi: 10.1016/j.vaccine.2013.06.009. Epub 2013 Jun 17.
PMID: 23791680

[Cloning and expression of Neisserial surface protein A gene and its applicalion in detection of serum specific antibody]
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013 Apr;29(4):414-7.
PMID: 23643173

The relative roles of factor H binding protein, neisserial surface protein A, and lipooligosaccharide sialylation in regulation of the alternative pathway of complement on meningococci
J Immunol. 2012 May 15;188(10):5063-72. doi: 10.4049/jimmunol.1103748. Epub 2012 Apr 13.
PMID: 22504643

Enhanced bacteremia in human factor H transgenic rats infected by Neisseria meningitidis
Infect Immun. 2012 Feb;80(2):643-50. doi: 10.1128/IAI.05604-11. Epub 2011 Nov 21.
PMID: 22104107

Neisseria gonorrhoeae NspA induces specific bactericidal and opsonic antibodies in mice
Clin Vaccine Immunol. 2011 Nov;18(11):1817-22. doi: 10.1128/CVI.05245-11. Epub 2011 Sep 14.
PMID: 21918113

Meningococcal group W-135 and Y capsular polysaccharides paradoxically enhance activation of the alternative pathway of complement
J Biol Chem. 2011 Mar 11;286(10):8297-307. doi: 10.1074/jbc.M110.184838. Epub 2011 Jan 18.
PMID: 21245150

Conformational epitopes recognized by protective anti-neisserial surface protein A antibodies
Infect Immun. 2003 Dec;71(12):6844-9. doi: 10.1128/iai.71.12.6844-6849.2003.
PMID: 14638771

Crystal structure of Neisserial surface protein A (NspA), a conserved outer membrane protein with vaccine potential
J Biol Chem. 2003 Jul 4;278(27):24825-30. doi: 10.1074/jbc.M302803200. Epub 2003 Apr 26.
PMID: 12716881

The role of neisserial Opa proteins in interactions with host cells
Trends Microbiol. 1998 Dec;6(12):489-95. doi: 10.1016/s0966-842x(98)01365-1.
PMID: 10036728

Highly conserved Neisseria meningitidis surface protein confers protection against experimental infection
J Exp Med. 1997 Apr 7;185(7):1173-83. doi: 10.1084/jem.185.7.1173.
PMID: 9104804

Proteins in this family with 3D-structure
View Entry
Description
Organism
Length
# strands
Surface protein A
Neisseria meningitidis
174
8
Ail/Lom family outer membrane beta-barrel protein
Neisseria gonorrhoeae
238
8


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