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The Helicobacter Outer Membrane Porin (HOP-1) Family 1 [Function: Adhesion] Seed alignment | Full alignment in OMPdb

This family consists of several outer membrane proteins found only in Helicobacter pylori, which is the causative agent of gastritis and peptic ulceration in humans. The outer membrane proteome profile of Helicobacter pylori differs from that of other Gram-negative bacteria. Outer membrane proteins of Helicobacter pylori are characterized mainly as adhesins and porins and extensive C-terminal sequence similarity between these proteins has been used to define this large paralogous family.


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Literature references

Topology and membrane interaction of Helicobacter pylori ComB proteins involved in natural transformation competence
Int J Med Microbiol. 2003 Jun;293(2-3):153-65. doi: 10.1078/1438-4221-00258.
PMID: 12868652

Characterization of four members of a multigene family encoding outer membrane proteins of Helicobacter pylori and their potential for vaccination
Microbes Infect. 2001 Mar;3(3):171-9. doi: 10.1016/s1286-4579(01)01377-6.
PMID: 11358711

Isolation and characterization of a family of porin proteins from Helicobacter pylori
Infect Immun. 1995 Apr;63(4):1567-72. doi: 10.1128/IAI.63.4.1567-1572.1995.
PMID: 7534278

Isolation and characterization of a conserved porin protein from Helicobacter pylori
J Bacteriol. 1995 Oct;177(19):5447-52. doi: 10.1128/jb.177.19.5447-5452.1995.
PMID: 7559328

Functional expression in Escherichia coli and membrane topology of porin HopE, a member of a large family of conserved proteins in Helicobacter pylori
J Bacteriol. 2000 May;182(9):2370-5. doi: 10.1128/jb.182.9.2370-2375.2000.
PMID: 10762234


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