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Vibrio parahaemolyticus is a significant Gram-negative halophilous pathogen. As a result of the consumption of seafood, it may cause a harmful seafood-borne illness in humans. In addition, it causes a wide range of disease in aquatic animals. Avoiding the use of antibiotics, VP1243 is a protective antigen which showed a high effective antimicrobial activity against the mentioned organism. VP1243 is widely distributed and highly conserved among the major Vibrio species. VP1243 is considered as a hopeful candidate against the Vibrio infections. Western blotting analysis revealed that VP1243 is an outer membrane protein. The first 19 amino acids function as a signal peptide according to SignalP. VP1243 forms 10 transmembrane ß strands based on PRED-TMBB2 prediction.
Evaluation of the ß-barrel outer membrane protein VP1243 as a candidate antigen for a cross-protective vaccine against Vibrio infections
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Landscape of Eukaryotic Transmembrane Beta Barrel Proteins
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Helix-strand interaction regulates stability and aggregation of the human mitochondrial membrane protein channel VDAC3
J Gen Physiol. 2019 Apr 1;151(4):489-504. doi: 10.1085/jgp.201812272. Epub 2019 Jan 23.
Identification of a novel vaccine candidate by immunogenic screening of Vibrio parahaemolyticus outer membrane proteins
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Influence of protein-micelle ratios and cysteine residues on the kinetic stability and unfolding rates of human mitochondrial VDAC-2
PLoS One. 2014 Jan 29;9(1):e87701. doi: 10.1371/journal.pone.0087701. eCollection 2014.
The structural biology of ß-barrel membrane proteins: a summary of recent reports
Curr Opin Struct Biol. 2011 Aug;21(4):523-31. doi: 10.1016/j.sbi.2011.05.005. Epub 2011 Jun 28.