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Vibrio parahaemolyticus is a significant Gram-negative halophilous pathogen. As a result of the consumption of seafood, it may cause a harmful seafood-borne illness in humans. In addition, it causes a wide range of disease in aquatic animals. Avoiding the use of antibiotics, VP1243 is a protective antigen which showed a high effective antimicrobial activity against the mentioned organism. VP1243 is widely distributed and highly conserved among the major Vibrio species. VP1243 is considered as a hopeful candidate against the Vibrio infections. Western blotting analysis revealed that VP1243 is an outer membrane protein. The first 19 amino acids function as a signal peptide according to SignalP. VP1243 forms 10 transmembrane beta strands based on PRED-TMBB2 prediction.
Evaluation of the ?-barrel outer membrane protein VP1243 as a candidate antigen for a cross-protective vaccine against Vibrio infections
Microb Pathog. 2020 Oct;147:104419. doi: 10.1016/j.micpath.2020.104419. Epub 2020 Aug 5.