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The OEP80 Family [Function: Biogenesis/Secretion] Seed alignment | Full alignment in OMPdb

OEP80 is another OMP85 homolog, whose function is obscure. It is also referred to as TOC75-V since it is encoded in the V chromosome of Arabidopsis thaliana. Multiple structural studies in OMP85 homologs have detected a conserved folding pattern of POTRA domains and the unparalleled arrangement of the transmembrane beta barrel. Phylogenetic analysis supported the grouping of TOC75 and OEP80 sister to OMP85. OEP80 has a vital role in the insertion of beta barrel proteins into the chloroplastic outer membrane.OEP80 has a cleavable N-terminal signal and, in addition, its POTRA domains are exposed to the intermembrane space of chloroplast. Thus, OEP80 seems to interact with chloroplast substrates.

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Literature references

Evolution and targeting of Omp85 homologs in the chloroplast outer envelope membrane
Front Plant Sci. 2014 Oct 13;5:535. doi: 10.3389/fpls.2014.00535. eCollection 2014.
PMID: 25352854

Emerging roles of the chloroplast outer envelope membrane
Trends Plant Sci. 2011 Oct;16(10):550-7. doi: 10.1016/j.tplants.2011.06.005. Epub 2011 Jul 19.
PMID: 21775189

A Toc75-like protein import channel is abundant in chloroplasts
EMBO Rep. 2002 Jun;3(6):557-62. doi: 10.1093/embo-reports/kvf110. Epub 2002 May 24.
PMID: 12034753

Structure and function of POTRA domains of Omp85/TPS superfamily
Int Rev Cell Mol Biol. 2014;308:1-34. doi: 10.1016/B978-0-12-800097-7.00001-4.
PMID: 24411168

Structural insight into the biogenesis of ?-barrel membrane proteins
Nature. 2013 Sep 19;501(7467):385-90. doi: 10.1038/nature12521. Epub 2013 Sep 1.
PMID: 23995689

The structural basis of autotransporter translocation by TamA
Nat Struct Mol Biol. 2013 Nov;20(11):1318-20. doi: 10.1038/nsmb.2689. Epub 2013 Sep 22.
PMID: 24056943

Structure of the membrane protein FhaC: a member of the Omp85-TpsB transporter superfamily
Science. 2007 Aug 17;317(5840):957-61. doi: 10.1126/science.1143860.
PMID: 17702945

Toc75-V/OEP80 is processed during translocation into chloroplasts, and the membrane-embedded form exposes its POTRA domain to the intermembrane space
FEBS Open Bio. 2020 Mar;10(3):444-454. doi: 10.1002/2211-5463.12791. Epub 2020 Feb 17.
PMID: 31953987

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