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The TOC75 Family [Function: Biogenesis/Secretion] Seed alignment | Full alignment in OMPdb

The Translocon protein found at the outer-envelope-membrane of chloroplasts (TOC75) is a beta barrel integral membrane protein that belongs to the OMP85 superfamily. It acts as the protein translocation pathway on the outer membrane of chloroplast. POTRA domains of TOC75 together with TIC236 may form a continuous chaperone pathway for the translocation of pre-proteins across the intermembrane space.


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Literature references

Two evolutionarily conserved essential beta-barrel proteins in the chloroplast outer envelope membrane
Biosci Trends. 2009 Oct;3(5):168-78.
PMID: 20103843

Topology studies of the chloroplast protein import channel Toc75
Biol Chem. 2000 Aug;381(8):687-93. doi: 10.1515/BC.2000.089.
PMID: 11030426

A molecular-genetic study of the Arabidopsis Toc75 gene family
Plant Physiol. 2005 Jun;138(2):715-33. doi: 10.1104/pp.105.063289. Epub 2005 May 20.
PMID: 15908591

TIC236 links the outer and inner membrane translocons of the chloroplast
Nature. 2018 Dec;564(7734):125-129. doi: 10.1038/s41586-018-0713-y. Epub 2018 Nov 21.
PMID: 30464337


Elixir UTH dib compgen