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The TGD4 Family [Function: Biogenesis/Secretion] Seed alignment | Full alignment in OMPdb

TGD4 is conserved evolutionarily from green algae to higher plants. As indicated by the secondary structure prediction made with PROF. TGD4 appears to form multiple beta sheets especially near the C-terminus. Furthermore, it is proposed that TGD4 is a transmembrane protein, probably a beta barrel protein, present in the outer membrane of the chloroplast with its N-terminus slightly faced to the cytosol.

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Literature references

The PredictProtein server
Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W321-6. doi: 10.1093/nar/gkh377.
PMID: 15215403

Lipid trafficking between the endoplasmic reticulum and the plastid in Arabidopsis requires the extraplastidic TGD4 protein
Plant Cell. 2008 Aug;20(8):2190-204. doi: 10.1105/tpc.108.061176. Epub 2008 Aug 8.
PMID: 18689504

TGD4 involved in endoplasmic reticulum-to-chloroplast lipid trafficking is a phosphatidic acid binding protein
Plant J. 2012 May;70(4):614-23. doi: 10.1111/j.1365-313X.2012.04900.x. Epub 2012 Feb 14.
PMID: 22269056

Elixir UTH dib compgen