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The FadL Outer Membrane Protein (FadL) Family [Function: Receptor] Seed alignment | Full alignment in OMPdb

This family includes several distantly related outer membrane proteins, sequenced from different bacterial species. The family is named after the Escherichia coli FadL protein which functions in transporting long chain fatty acids across the outer membrane. Other members (such as XylN and TodX) are implicated in the transport of aromatic compounds such as toluene, m-xylene and its analogs. All members seem to function as monomers. The 3D structure of FadL at high resolution shows that the protein forms a monomeric ß-barrel composed of 14 beta strands, that is occluded by a central hatch domain. The hatch domain is composed of residues in the N-terminus in a similar manner with that found in the TonB-dependent receptors. The hydrophobic compounds probably bind to multiple sites in the channel and use a transport mechanism that involves a spontaneous conformational change in the hatch region.


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Representative image:  fam_img

Literature references

The TOL plasmid pWW0 xylN gene product from Pseudomonas putida is involved in m-xylene uptake
J Bacteriol. 2001 Nov;183(22):6662-6. doi: 10.1128/JB.183.22.6662-6666.2001.
PMID: 11673437

Bacterial long chain fatty acid transport: gateway to a fatty acid-responsive signaling system
J Biol Chem. 2004 Nov 26;279(48):49563-6. doi: 10.1074/jbc.R400026200. Epub 2004 Aug 30.
PMID: 15347640

Identification of a membrane protein and a truncated LysR-type regulator associated with the toluene degradation pathway in Pseudomonas putida F1
Mol Gen Genet. 1995 Mar 10;246(5):570-9. doi: 10.1007/BF00298963.
PMID: 7535376

The FadL family: unusual transporters for unusual substrates
Curr Opin Struct Biol. 2005 Aug;15(4):401-7. doi: 10.1016/j.sbi.2005.06.003.
PMID: 16005205

Outer-membrane transport of aromatic hydrocarbons as a first step in biodegradation
Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8601-6. doi: 10.1073/pnas.0801264105. Epub 2008 Jun 16.
PMID: 18559855

Crystal structure of the long-chain fatty acid transporter FadL
Science. 2004 Jun 4;304(5676):1506-9. doi: 10.1126/science.1097524.
PMID: 15178802

Transmembrane passage of hydrophobic compounds through a protein channel wall
Nature. 2009 Mar 19;458(7236):367-70. doi: 10.1038/nature07678. Epub 2009 Feb 1.
PMID: 19182779

Ligand-gated diffusion across the bacterial outer membrane
Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10121-6. doi: 10.1073/pnas.1018532108. Epub 2011 May 18.
PMID: 21593406

Proteins in this family with 3D-structure

Q9RBW8

A5W4F4

P10384

Q9HVJ6

Q51971


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