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The Mitochondrial and Plastid Porin MDM10 Family [Function: Biogenesis/Secretion] Seed alignment | Full alignment | TC-DB page | ||||
MDM10 is a key protein for mitochondrial morphology and inheritance. Along with Mmm1 and Mdm12, MDM10 enables the connection of mitochondria to the cytoskeleton. MDM10 is also one of TOB complex members and associated with the assembly of the TOM complex. Immunological and biochemical analysis revealed that, MDM10 is an integral outer membrane protein. Homology modelling indicated that, MDM10 is a ß barrel protein according to a b-signal which is required for the biogenesis of ß barrel proteins | ||||
| Literature references | ||||
Landscape of Eukaryotic Transmembrane Beta Barrel Proteins J Proteome Res. 2020 Mar 6;19(3):1209-1221. doi: 10.1021/acs.jproteome.9b00740. Epub 2020 Feb 11. PMID: 32008325 | ||||
In silico analysis of coevolution among ERMES proteins, Pex11, and Lam6 Can J Microbiol. 2017 Dec;63(12):984-997. doi: 10.1139/cjm-2017-0460. Epub 2017 Oct 6. PMID: 28985476 | ||||
Identification of new channels by systematic analysis of the mitochondrial outer membrane J Cell Biol. 2017 Nov 6;216(11):3485-3495. doi: 10.1083/jcb.201706043. Epub 2017 Sep 15. PMID: 28916712 | ||||
Separating mitochondrial protein assembly and endoplasmic reticulum tethering by selective coupling of Mdm10 Nat Commun. 2016 Oct 10;7:13021. doi: 10.1038/ncomms13021. PMID: 27721450 | ||||
Trypanosomal TAC40 constitutes a novel subclass of mitochondrial ß-barrel proteins specialized in mitochondrial genome inheritance Proc Natl Acad Sci U S A. 2014 May 27;111(21):7624-9. doi: 10.1073/pnas.1404854111. Epub 2014 May 12. PMID: 24821793 | ||||
Mdm10 is an ancient eukaryotic porin co-occurring with the ERMES complex Biochim Biophys Acta. 2013 Dec;1833(12):3314-3325. doi: 10.1016/j.bbamcr.2013.10.006. Epub 2013 Oct 14. PMID: 24135058 | ||||
Mcp1 and Mcp2, two novel proteins involved in mitochondrial lipid homeostasis J Cell Sci. 2013 Aug 15;126(Pt 16):3563-74. doi: 10.1242/jcs.121244. Epub 2013 Jun 18. PMID: 23781023 | ||||
Analysis of mutations in Neurospora crassa ERMES components reveals specific functions related to ß-barrel protein assembly and maintenance of mitochondrial morphology PLoS One. 2013 Aug 5;8(8):e71837. doi: 10.1371/journal.pone.0071837. Print 2013. PMID: 23940790 | ||||
Phylogenetic and coevolutionary analysis of the ß-barrel protein family comprised of mitochondrial porin (VDAC) and Tom40 Biochim Biophys Acta. 2012 Jun;1818(6):1502-19. doi: 10.1016/j.bbamem.2011.11.027. Epub 2011 Dec 4. PMID: 22178864 | ||||
Biogenesis of mitochondria: dual role of Tom7 in modulating assembly of the preprotein translocase of the outer membrane J Mol Biol. 2011 Jan 7;405(1):113-24. doi: 10.1016/j.jmb.2010.11.002. Epub 2010 Nov 6. PMID: 21059357 | ||||
Tom7 regulates Mdm10-mediated assembly of the mitochondrial import channel protein Tom40 J Biol Chem. 2010 Dec 31;285(53):41222-31. doi: 10.1074/jbc.M110.163238. Epub 2010 Oct 29. PMID: 21036907 | ||||
Roles of the Mdm10, Tom7, Mdm12, and Mmm1 proteins in the assembly of mitochondrial outer membrane proteins in Neurospora crassa Mol Biol Cell. 2010 May 15;21(10):1725-36. doi: 10.1091/mbc.e09-10-0844. Epub 2010 Mar 24. PMID: 20335503 | ||||
Mdm10 as a dynamic constituent of the TOB/SAM complex directs coordinated assembly of Tom40 EMBO Rep. 2010 Mar;11(3):187-93. doi: 10.1038/embor.2009.283. Epub 2010 Jan 29. PMID: 20111053 | ||||
Mitochondrial inheritance is required for MEN-regulated cytokinesis in budding yeast Curr Biol. 2009 Nov 3;19(20):1730-5. doi: 10.1016/j.cub.2009.08.041. Epub 2009 Oct 8. PMID: 19818621 | ||||
Mitochondrial protein sorting: differentiation of beta-barrel assembly by Tom7-mediated segregation of Mdm10 J Biol Chem. 2006 Aug 11;281(32):22819-26. doi: 10.1074/jbc.M602679200. Epub 2006 Jun 7. PMID: 16760475 | ||||
The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane Dev Cell. 2004 Jul;7(1):61-71. doi: 10.1016/j.devcel.2004.06.003. PMID: 15239954 | ||||
A protein complex containing Mdm10p, Mdm12p, and Mmm1p links mitochondrial membranes and DNA to the cytoskeleton-based segregation machinery Mol Biol Cell. 2003 Nov;14(11):4618-27. doi: 10.1091/mbc.e03-04-0225. Epub 2003 Sep 17. PMID: 13679517 | ||||
Regulation of mitochondrial morphology and inheritance by Mdm10p, a protein of the mitochondrial outer membrane J Cell Biol. 1994 Sep;126(6):1361-73. doi: 10.1083/jcb.126.6.1361. PMID: 8089171 | ||||
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