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The MDM10 Family [Function: Biogenesis/Secretion] Seed alignment | Full alignment in OMPdb

MDM10 is a key protein for mitochondrial morphology and inheritance. Along with Mmm1 and Mdm12, MDM10 enables the connection of mitochondria to the cytoskeleton. MDM10 is also one of TOB complex members and associated with the assembly of the TOM complex. Immunological and biochemical analysis revealed that, MDM10 is an integral outer membrane protein. Homology modelling indicated that, MDM10 is a beta barrel protein according to a b-signal which is required for the biogenesis of beta barrel proteins

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Literature references

Regulation of mitochondrial morphology and inheritance by Mdm10p, a protein of the mitochondrial outer membrane
J Cell Biol. 1994 Sep;126(6):1361-73. doi: 10.1083/jcb.126.6.1361.
PMID: 8089171

A protein complex containing Mdm10p, Mdm12p, and Mmm1p links mitochondrial membranes and DNA to the cytoskeleton-based segregation machinery
Mol Biol Cell. 2003 Nov;14(11):4618-27. doi: 10.1091/mbc.e03-04-0225. Epub 2003 Sep 17.
PMID: 13679517

The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane
Dev Cell. 2004 Jul;7(1):61-71. doi: 10.1016/j.devcel.2004.06.003.
PMID: 15239954

Mdm10 is an ancient eukaryotic porin co-occurring with the ERMES complex
Biochim Biophys Acta. 2013 Dec;1833(12):3314-3325. doi: 10.1016/j.bbamcr.2013.10.006. Epub 2013 Oct 14.
PMID: 24135058

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