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The VDAC Family [Function: Specific diffusion channels] Seed alignment | Full alignment | Pfam Wiki page

The voltage-dependent anion channel protein (VDAC) is the main protein of the mitochondrial outer membrane of all eukaryotes. VDAC regulates the movement of metabolites from the cytoplasm to the mitochondrion and vice-versa. Through this function, VDAC organizes various cellular processes like metabolism, apoptosis, calcium homeostasis and thus has an effect on a lot of diseases such as cancer, cardiovascular and neurodegenerative diseases. VDAC forms a ß barrel architecture constituted of 19 ß strands.


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Literature references


Evaluation of the ß-barrel outer membrane protein VP1243 as a candidate antigen for a cross-protective vaccine against Vibrio infections
Microb Pathog. 2020 Oct;147:104419. doi: 10.1016/j.micpath.2020.104419. Epub 2020 Aug 5.
PMID: 32768517

Landscape of Eukaryotic Transmembrane Beta Barrel Proteins
J Proteome Res. 2020 Mar 6;19(3):1209-1221. doi: 10.1021/acs.jproteome.9b00740. Epub 2020 Feb 11.
PMID: 32008325

Helix-strand interaction regulates stability and aggregation of the human mitochondrial membrane protein channel VDAC3
J Gen Physiol. 2019 Apr 1;151(4):489-504. doi: 10.1085/jgp.201812272. Epub 2019 Jan 23.
PMID: 30674561

Identification of a novel vaccine candidate by immunogenic screening of Vibrio parahaemolyticus outer membrane proteins
Vaccine. 2014 Oct 21;32(46):6115-21. doi: 10.1016/j.vaccine.2014.08.077. Epub 2014 Sep 16.
PMID: 25236587

Influence of protein-micelle ratios and cysteine residues on the kinetic stability and unfolding rates of human mitochondrial VDAC-2
PLoS One. 2014 Jan 29;9(1):e87701. doi: 10.1371/journal.pone.0087701. eCollection 2014.
PMID: 24494036

The structural biology of ß-barrel membrane proteins: a summary of recent reports
Curr Opin Struct Biol. 2011 Aug;21(4):523-31. doi: 10.1016/j.sbi.2011.05.005. Epub 2011 Jun 28.
PMID: 21719274

Proteins in this family with 3D-structure
View Entry
Description
Organism
Length
# strands
Mitochondrial distribution and morphology protein 10
Homo sapiens (Human)
283
19
Outer membrane efflux family protein
Mus musculus (Mouse)
296
19
Voltage-dependent anion-selective channel protein 2
Danio rerio (Zebrafish) (Brachydanio rerio)
283
19


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