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The VDAC Family [Function: Specific channels] Seed alignment | Full alignment in OMPdb | |
The voltage-dependent anion channel protein (VDAC) is the main protein of the mitochondrial outer membrane of all eukaryotes. VDAC regulates the movement of metabolites from the cytoplasm to the mitochondrion and vice-versa. Through this function, VDAC organizes various cellular processes like metabolism, apoptosis, calcium homeostasis and thus has an effect on a lot of diseases such as cancer, cardiovascular and neurodegenerative diseases. VDAC forms a beta barrel architecture constituted of 19 beta strands. | |
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Literature references | |
VDAC in cancer Biochim Biophys Acta Bioenerg. 2017 Aug;1858(8):665-673. doi: 10.1016/j.bbabio.2017.03.002. Epub 2017 Mar 7. PMID: 28283400 | |
Structure of the human voltage-dependent anion channel Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15370-5. doi: 10.1073/pnas.0808115105. Epub 2008 Oct 1. PMID: 18832158 | |
Solution structure of the integral human membrane protein VDAC-1 in detergent micelles Science. 2008 Aug 29;321(5893):1206-10. doi: 10.1126/science.1161302. PMID: 18755977 | |
The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17742-7. doi: 10.1073/pnas.0809634105. Epub 2008 Nov 6. PMID: 18988731 | |
Proteins in this family with 3D-structure | |
P21796 | |
Q60932 | |
Q8AWD0 |
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