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The VDAC Family [Function: Specific channels] Seed alignment | Full alignment in OMPdb

The voltage-dependent anion channel protein (VDAC) is the main protein of the mitochondrial outer membrane of all eukaryotes. VDAC regulates the movement of metabolites from the cytoplasm to the mitochondrion and vice-versa. Through this function, VDAC organizes various cellular processes like metabolism, apoptosis, calcium homeostasis and thus has an effect on a lot of diseases such as cancer, cardiovascular and neurodegenerative diseases. VDAC forms a beta barrel architecture constituted of 19 beta strands.

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Literature references

VDAC in cancer
Biochim Biophys Acta Bioenerg. 2017 Aug;1858(8):665-673. doi: 10.1016/j.bbabio.2017.03.002. Epub 2017 Mar 7.
PMID: 28283400

Structure of the human voltage-dependent anion channel
Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15370-5. doi: 10.1073/pnas.0808115105. Epub 2008 Oct 1.
PMID: 18832158

Solution structure of the integral human membrane protein VDAC-1 in detergent micelles
Science. 2008 Aug 29;321(5893):1206-10. doi: 10.1126/science.1161302.
PMID: 18755977

The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating
Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17742-7. doi: 10.1073/pnas.0809634105. Epub 2008 Nov 6.
PMID: 18988731

Proteins in this family with 3D-structure




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