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The Lysenin Family [Function: Non-specific channels] Seed alignment | Full alignment in OMPdb

Lysenin is a PFT of Eisena fetida and a member of the aerolysin family. It is a nonamer and forms an 18-strand smooth-walled tubular beta barrel attached to the outside by the C-terminal domains. It is a mushroom-like structure which has a transmembrane pore with a central stem built of a long beta barrel. Having a uniform and stable beta barrel through the entire length of protein makes lysenin an exception among PFTs.


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Literature references

Crystal structure of an invertebrate cytolysin pore reveals unique properties and mechanism of assembly
Nat Commun. 2016 May 12;7:11598. doi: 10.1038/ncomms11598.
PMID: 27176125


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