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Hemolysin, a heptameric porin, is secreted by pathogenic bacteria. The heptamer comprises a ring-like structure with an outer diameter of 135 Å. The channel pore consists of an upper large vestibule formed by beta prism and cytolysin domains, and the stem domains which form a 14-strand beta barrel.
Crystal structure of the Vibrio cholerae cytolysin heptamer reveals common features among disparate pore-forming toxins
Proc Natl Acad Sci U S A. 2011 May 3;108(18):7385-90. doi: 10.1073/pnas.1017442108. Epub 2011 Apr 18.