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The Cytohemolysin (CHL) Family [Function: Non-specific diffusion channels] Seed alignment | Full alignment | TC-DB page | ||||
Hemolysin, a heptameric porin, is secreted by Vibrio cholerae. The heptamer comprises a ring-like structure with an outer diameter of 135 Å. The channel pore consists of an upper large vestibule formed by ß prism and cytolysin domains, and the stem domains which form a 14-strand ß barrel. | ||||
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| Literature references | ||||
Diversity of virulence-associated genes in pathogenic Aeromonas hydrophila isolates and their in vivo modulation at varied water temperatures Microb Pathog. 2020 Oct;147:104424. doi: 10.1016/j.micpath.2020.104424. Epub 2020 Aug 6. PMID: 32771658 | ||||
Inhibition of interaction between Staphylococcus aureus α-hemolysin and erythrocytes membrane by hydrolysable tannins: structure-related activity study Sci Rep. 2020 Jul 7;10(1):11168. doi: 10.1038/s41598-020-68030-1. PMID: 32636484 | ||||
Development of a monoclonal antibody for specific detection of Vibrio parahaemolyticus and analysis of its antigen J Microbiol Methods. 2020 Jun;173:105919. doi: 10.1016/j.mimet.2020.105919. Epub 2020 Apr 11. PMID: 32289368 | ||||
Occurrence and Abundance of Pathogenic Vibrio Species in Raw Oysters at Retail Seafood Markets in Northwestern Mexico J Food Prot. 2019 Dec;82(12):2094-2099. doi: 10.4315/0362-028X.JFP-19-237. PMID: 31724880 | ||||
Induction of erythrocyte microvesicles by Escherichia Coli Alpha hemolysin Biochem J. 2019 Nov 29;476(22):3455-3473. doi: 10.1042/BCJ20190546. PMID: 31661116 | ||||
Potential pathogenicity and antibiotic resistance of aquatic Vibrio isolates from freshwater in Slovakia Folia Microbiol (Praha). 2020 Jun;65(3):545-555. doi: 10.1007/s12223-019-00760-w. Epub 2019 Nov 26. PMID: 31773555 | ||||
Molecular mechanisms of Vibrio parahaemolyticus pathogenesis Microbiol Res. 2019 May;222:43-51. doi: 10.1016/j.micres.2019.03.003. Epub 2019 Mar 8. PMID: 30928029 | ||||
Dysregulated hemolysin liberates bacterial outer membrane vesicles for cytosolic lipopolysaccharide sensing PLoS Pathog. 2018 Aug 23;14(8):e1007240. doi: 10.1371/journal.ppat.1007240. eCollection 2018 Aug. PMID: 30138458 | ||||
Crystal structure of the Vibrio cholerae cytolysin heptamer reveals common features among disparate pore-forming toxins Proc Natl Acad Sci U S A. 2011 May 3;108(18):7385-90. doi: 10.1073/pnas.1017442108. Epub 2011 Apr 18. PMID: 21502531 | ||||
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