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The SprA Family [Function: Biogenisis / Secretion] Seed alignment | Full alignment in OMPdb

The Gram-negative Fibrobacteres-Chlorobi-Bacteroidetes superphylum has a protein export pathway called the type 9 secretion system (T9SS), which is considered as an important determinant of pathogenicity in serious periodontal disease. These bacteroidetes are famous for the quick and unique gliding motility where their cell surface adhesins move on helical tracks (Shrivastava, Roland, and Berg 2016). Cryo-electron microscopy revealed that SprA is the translocon of T9SS. Furthermore, SprA consists of a large transmembrane beta barrel of 36 strands. The SprA barrel has a lateral entry to the external membrane surface because the barrel pore on the extracellular end is closed.


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Literature references

The Type IX Secretion System (T9SS): Highlights and Recent Insights into Its Structure and Function
Front Cell Infect Microbiol. 2017 May 26;7:215. doi: 10.3389/fcimb.2017.00215. eCollection 2017.
PMID: 28603700

Type 9 secretion system structures reveal a new protein transport mechanism
Nature. 2018 Dec;564(7734):77-82. doi: 10.1038/s41586-018-0693-y. Epub 2018 Nov 7.
PMID: 30405243

Proteins in this family with 3D-structure

Q5I6C7


Elixir UTH dib compgen