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The Poly Acetyl Glucosamine Porin (PgaA) Family [Function: Biogenesis / Secretion] Seed alignment | Full alignment | TC-DB page | ||||
PgaA controls the translocation of de-N-acetylated poly-b-1,6-N-acetyl-d-glucosamine (dPNAG) polymer into the bacterial outer membrane. dPNAG is crucial for biofilm adhesion and has an important role in the maintenance and development of biofilms integration for various bacterial species. PgaA ß barrel domain (513-807) consists of 16 antiparallel transmembrane ß sheets with b1 and b16 strands interlocking. | ||||
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| Literature references | ||||
Extended spectrum ß-lactamase producing uropathogenic Escherichia coli and the correlation of biofilm with antibiotics resistance in Nepal Ann Clin Microbiol Antimicrob. 2019 Dec 17;18(1):42. doi: 10.1186/s12941-019-0340-y. PMID: 31847837 | ||||
Sub-minimum inhibitory concentrations of colistin and polymyxin B promote Acinetobacter baumannii biofilm formation PLoS One. 2018 Mar 19;13(3):e0194556. doi: 10.1371/journal.pone.0194556. eCollection 2018. PMID: 29554105 | ||||
Alternative pathways for Escherichia coli biofilm formation revealed by sRNA overproduction Mol Microbiol. 2017 Jul;105(2):309-325. doi: 10.1111/mmi.13702. Epub 2017 May 18. PMID: 28470798 | ||||
Structural Basis for Translocation of a Biofilm-supporting Exopolysaccharide across the Bacterial Outer Membrane J Biol Chem. 2016 May 6;291(19):10046-57. doi: 10.1074/jbc.M115.711762. Epub 2016 Mar 8. PMID: 26957546 | ||||
Surface Polysaccharide Mutants Reveal that Absence of O Antigen Reduces Biofilm Formation of Actinobacillus pleuropneumoniae Infect Immun. 2015 Oct 19;84(1):127-37. doi: 10.1128/IAI.00912-15. Print 2016 Jan. PMID: 26483403 | ||||
RNA remodeling by bacterial global regulator CsrA promotes Rho-dependent transcription termination Genes Dev. 2014 Jun 1;28(11):1239-51. doi: 10.1101/gad.240192.114. PMID: 24888591 | ||||
Dual function of the McaS small RNA in controlling biofilm formation Genes Dev. 2013 May 15;27(10):1132-45. doi: 10.1101/gad.214734.113. Epub 2013 May 10. PMID: 23666921 | ||||
Comparison of three methods to study biofilm formation by clinical strains of Escherichia coli Diagn Microbiol Infect Dis. 2013 Mar;75(3):252-5. doi: 10.1016/j.diagmicrobio.2012.11.019. Epub 2013 Jan 11. PMID: 23313082 | ||||
| Proteins in this family with 3D-structure | ||||
View Entry | Description | Organism | Length | # strands |