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The Poly Acetyl Glucosamine Porin (PgaA) Family [Function: Biogenesis / Secretion] Seed alignment | Full alignment | TC-DB page

PgaA controls the translocation of de-N-acetylated poly-b-1,6-N-acetyl-d-glucosamine (dPNAG) polymer into the bacterial outer membrane. dPNAG is crucial for biofilm adhesion and has an important role in the maintenance and development of biofilms integration for various bacterial species. PgaA ß barrel domain (513-807) consists of 16 antiparallel transmembrane ß sheets with b1 and b16 strands interlocking.

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Literature references

Extended spectrum ß-lactamase producing uropathogenic Escherichia coli and the correlation of biofilm with antibiotics resistance in Nepal
Ann Clin Microbiol Antimicrob. 2019 Dec 17;18(1):42. doi: 10.1186/s12941-019-0340-y.
PMID: 31847837

Sub-minimum inhibitory concentrations of colistin and polymyxin B promote Acinetobacter baumannii biofilm formation
PLoS One. 2018 Mar 19;13(3):e0194556. doi: 10.1371/journal.pone.0194556. eCollection 2018.
PMID: 29554105

Alternative pathways for Escherichia coli biofilm formation revealed by sRNA overproduction
Mol Microbiol. 2017 Jul;105(2):309-325. doi: 10.1111/mmi.13702. Epub 2017 May 18.
PMID: 28470798

Structural Basis for Translocation of a Biofilm-supporting Exopolysaccharide across the Bacterial Outer Membrane
J Biol Chem. 2016 May 6;291(19):10046-57. doi: 10.1074/jbc.M115.711762. Epub 2016 Mar 8.
PMID: 26957546

Surface Polysaccharide Mutants Reveal that Absence of O Antigen Reduces Biofilm Formation of Actinobacillus pleuropneumoniae
Infect Immun. 2015 Oct 19;84(1):127-37. doi: 10.1128/IAI.00912-15. Print 2016 Jan.
PMID: 26483403

RNA remodeling by bacterial global regulator CsrA promotes Rho-dependent transcription termination
Genes Dev. 2014 Jun 1;28(11):1239-51. doi: 10.1101/gad.240192.114.
PMID: 24888591

Dual function of the McaS small RNA in controlling biofilm formation
Genes Dev. 2013 May 15;27(10):1132-45. doi: 10.1101/gad.214734.113. Epub 2013 May 10.
PMID: 23666921

Comparison of three methods to study biofilm formation by clinical strains of Escherichia coli
Diagn Microbiol Infect Dis. 2013 Mar;75(3):252-5. doi: 10.1016/j.diagmicrobio.2012.11.019. Epub 2013 Jan 11.
PMID: 23313082

Proteins in this family with 3D-structure
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