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The Intracellular Bacteria Surface Antigen Family [Function: Adhesion] Seed alignment | Full alignment in OMPdb

This family includes a number of bacterial surface antigens expressed on the surface of intracellular endosymbiotic pathogens belonging to various species of Rickettsiales, such as Anaplasma, Wolbachia and Ehrlichia. It is a diverse family, believed to consist of adhesins. The WSP protein of Wolbachia, the P28 antigen of Ehrlichia and the P44 antigen of Anaplasma are well-studied examples of such proteins. P44 has been recently shown to possess porin activity.


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Literature references

Porin activity of Anaplasma phagocytophilum outer membrane fraction and purified P44
J Bacteriol. 2007 Mar;189(5):1998-2006. doi: 10.1128/JB.01548-06. Epub 2006 Dec 15.
PMID: 17172334

Cloning and characterization of a gene encoding the major surface protein of the bacterial endosymbiont Wolbachia pipientis
J Bacteriol. 1998 May;180(9):2373-8. doi: 10.1128/JB.180.9.2373-2378.1998.
PMID: 9573188

Mosaic nature of the wolbachia surface protein
J Bacteriol. 2005 Aug;187(15):5406-18. doi: 10.1128/JB.187.15.5406-5418.2005.
PMID: 16030235

Expression of members of the 28-kilodalton major outer membrane protein family of Ehrlichia chaffeensis during persistent infection
Infect Immun. 2004 Aug;72(8):4336-43. doi: 10.1128/IAI.72.8.4336-4343.2004.
PMID: 15271888

Derivation of the complete msp4 gene sequence of Anaplasma marginale without cloning
Gene. 1993 Dec 22;136(1-2):291-4. doi: 10.1016/0378-1119(93)90482-i.
PMID: 8294020

Characterization of a major outer membrane protein multigene family in Ehrlichia ruminantium
Gene. 2004 Apr 14;330:159-68. doi: 10.1016/j.gene.2004.01.020.
PMID: 15087135

Anaplasma phagocytophilum MSP2(P44)-18 predominates and is modified into multiple isoforms in human myeloid cells
Infect Immun. 2008 May;76(5):2090-8. doi: 10.1128/IAI.01594-07. Epub 2008 Feb 19.
PMID: 18285495


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